Objective
The project has the objective of resolving uncertainties in the risk estimates for radiation induced cancer which are the basis of protection regulations. Updated cancer incidence and mortality data from the epidemiological follow-up of the atomic bomb survivors and from medical cohorts will be analysed, and the results will be used for improved risk models. The major open questions concern the pattern of cancer risk in different tissues over lifetime and the dependences on age at exposure, dose, radiation quality, and temporal distribution of exposure.
The proposed research contains several tasks. A first task (University of Munich) is the development of improved statistical and numerical methods for risk modelling. This includes the development, and the implementation in generally available software, of an algorithm that allows modelling of acute as well as continued exposures, and that permits the maximum likelihood evaluation of features, such as the distribution of latent periods. In a further refinement the algorithms will be extended to permit non-parametric modelling. A second task (INSERM, Villejuif, NRPB, Chilton) consists in the statistical analysis and the numerical quantification of uncertainties in risk estimates in their dependence on errors in dose estimates and model parameters. The methods resulting from both tasks will, in cooperation of the different groups, be applied to the data from the radioepidemiological studies to generate improved risk models for use in radiation protection with special emphasis on age dependences, the projection of risk in time, and the transfer of risk estimates between populations. A third task (NRPB, Chilton) is the study and improvement of mechanistic models of radiation induced cancer and the comparison of these models with the empirical results. In view of the critical importance in radiation protection of risk estimates for exposures early in life, two hospitals in Sweden (Karolinska Hospital, Stockholm, Sahlgren`s Hospital, Gothenburg) and one institution in France (Institut Gustave-Roussy, Villejuif) will cooperate on a newly defined large cohort of children who were radiation exposed for the treatment of skin hemangioma. Precise organ dependent dosimetry will be established for this cohort and cancer incidence will be assessed and followed further. The resulting dependences on age, time, tumor location and dose will be compared to the data from the atomic bomb survivors, to obtain improved cancer risk estimates for radiation exposure in childhood.
Fields of science (EuroSciVoc)
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80336 MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.