Objective * To identify protective antigens in lymphatic Filariasis suitable for vaccine use.* To measure human antibody and T cell responses to these antigens. * To clone and express major T cell immunogens as recombinants.* To express selected recombinant filarial antigens for vaccine tests in animals.* To enhance expertise and research resources of endemic count scientists.Expected Outcome* Identification of a panel of immune individuals whose serological and lymphocyte reactivities will define key in immunity.* Identification of the major T cell antigens in lymphatic Filariasis, and their cloning and expression in a variety of vectors.* Evaluation of potential vaccine antigens against lymphatic Filariasis in rodent model systems.* Identification of subjects exposed to Filariasis transmission but show evident immunity.* Measurement of antibody responses to a range of recombinant antigens.* Identification and cloning of filarial antigens which most strongly stimulate T cells.* Analysis of different geographic strains of Brugia malayi.* Expression of filarial T cell for vaccine testing in rodent models. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Topic(s) 03010302 - Research on the tools for prevention and the fight against the predominant diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator University of Edinburgh EU contribution No data Address West Mains Road EH9 3JT Edinburgh United Kingdom See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom EU contribution No data Address SW7 2AY London See on map Total cost No data LEIDEN UNIVERSITY Netherlands EU contribution No data Address 62,Wassenaarseweg 62 2300 RC LEIDEN See on map Total cost No data Shanghai Second Medical University China EU contribution No data Address 280,South Chongqing Road 200025 Shanghai See on map Total cost No data UNIVERSITY OF INDONESIA Indonesia EU contribution No data Address 6,Salemba Raya 6 10430 JAKARTA See on map Total cost No data