Skip to main content

T cell responsiveness and productive antigens filariasis vaccine de velopment

Objective

* To identify protective antigens in lymphatic Filariasis suitable for vaccine use.
* To measure human antibody and T cell responses to these antigens.
* To clone and express major T cell immunogens as recombinants.
* To express selected recombinant filarial antigens for vaccine tests in animals.
* To enhance expertise and research resources of endemic count scientists.
Expected Outcome

* Identification of a panel of immune individuals whose serological and lymphocyte reactivities will define key in immunity.
* Identification of the major T cell antigens in lymphatic Filariasis, and their cloning and expression in a variety of vectors.
* Evaluation of potential vaccine antigens against lymphatic Filariasis in rodent model systems.
* Identification of subjects exposed to Filariasis transmission but show evident immunity.
* Measurement of antibody responses to a range of recombinant antigens.
* Identification and cloning of filarial antigens which most strongly stimulate T cells.
* Analysis of different geographic strains of Brugia malayi.
* Expression of filarial T cell for vaccine testing in rodent models.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

University of Edinburgh
Address
West Mains Road
EH9 3JT Edinburgh
United Kingdom

Participants (4)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address

SW7 2AY London
LEIDEN UNIVERSITY
Netherlands
Address
62,Wassenaarseweg 62
2300 RC Leiden
Shanghai Second Medical University
China
Address
280,South Chongqing Road
200025 Shanghai
UNIVERSITY OF INDONESIA
Indonesia
Address
6,Salemba Raya 6
10430 Jakarta