* To identify protective antigens in lymphatic Filariasis suitable for vaccine use.
* To measure human antibody and T cell responses to these antigens.
* To clone and express major T cell immunogens as recombinants.
* To express selected recombinant filarial antigens for vaccine tests in animals.
* To enhance expertise and research resources of endemic count scientists.
* Identification of a panel of immune individuals whose serological and lymphocyte reactivities will define key in immunity.
* Identification of the major T cell antigens in lymphatic Filariasis, and their cloning and expression in a variety of vectors.
* Evaluation of potential vaccine antigens against lymphatic Filariasis in rodent model systems.
* Identification of subjects exposed to Filariasis transmission but show evident immunity.
* Measurement of antibody responses to a range of recombinant antigens.
* Identification and cloning of filarial antigens which most strongly stimulate T cells.
* Analysis of different geographic strains of Brugia malayi.
* Expression of filarial T cell for vaccine testing in rodent models.
Funding SchemeCSC - Cost-sharing contracts
SW7 2AY London
2300 RC Leiden