Objetivo Glutamate is the major excitatory neurotransmitter mediating communication between neurons in the brain. In the cerebellum glutamatergic transmission underlies information processing, contributing to the control of movement of the body, and thereafter changes in the strength of glutamatergic synapses may allow the brain to store patterns of motor activity. Although the basic mode of operation of cerebellar glutamatergic synapses is understood, there are severe defects in our knowledge of: how the strengths of these synapses may be modulated during normal function in pathological conditions like brain anoxia and during development of the nervous system. In order better to understand the topics outlined above, patch-clamp techniques will be used on slices of cerebellum in vitro to study the fundamental properties of cerebellar glutamatergic synapses. In particular, the effects of the modulatory agents adenosine, arachidonic acid, enkephalin and corticotropin releasing factor on the synapses from parallel fibres and climbing fibres to Purkinje cells will be tested, with a view to understanding how the gains of these synapses are adjusted on short and long time scales. These experiments will significantly improve the understanding of information processing in the cerebellum, and may give insight into how it malfunctions in pathological conditions. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 45 - Pharmacology Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador UNIVERSITY COLLEGE LONDON Aportación de la UE Sin datos Dirección Gower Street LONDON Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Ecole Normale Supérieure Francia Aportación de la UE Sin datos Dirección 75230 Paris Ver en el mapa Coste total Sin datos National Academy of Sciences of Ukraine Ucrania Aportación de la UE Sin datos Dirección GSP 252601 Kiev Ver en el mapa Coste total Sin datos
