Cel Ageing is the single most important factor in the onset of disease in the European population. An understanding of the molecular and physiological mechanisms that cause ageing is essential for the rational intervention of age-related disease. Simple model systems that exhibit ageing provide and economical means to obtain this understanding. We shall determine the genes and physiological mechanisms that cause ageing in Caenorhabditis elegant with a view to targeting processes that underlie age-associated disease in humans. This will be achieved by an extensive, interdisciplinary analysis of a series of genetic variants that exhibit greatly slowed rates of ageing resulting in life span control ageing rate and 300% (Age mutants). This analysis will reveal both regulatory mechanisms that control ageing rate and downstream mechanisms that constitute the molecular and physiological causes of ageing. We predict that many of the mechanisms we uncover will be universally linked to ageing in all animals and that consequently the targeting of these mechanisms will ameliorate age-related disease or postpone its onset. Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-6. - Key action The Ageing Population and Disabilities Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator GENT UNIVERSITY Wkład UE Brak danych Adres K.L. Ledeganckstraat 35 9000 GENT Belgia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko DEVGEN N.V. Belgia Wkład UE Brak danych Adres 266,Technologiepark 9 9052 ZWIJNAARDE Zobacz na mapie Koszt całkowity Brak danych MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Niemcy Wkład UE Brak danych Adres Ihnestrasse 73 14195 BERLIN Zobacz na mapie Koszt całkowity Brak danych NATIONAL UNIVERSITY OF IRELAND - MAYNOOTH Irlandia Wkład UE Brak danych Adres 47 Maynooth - Co. Kildare Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDAD PABLO DE OLAVIDE Hiszpania Wkład UE Brak danych Adres Carretra de Utrera Km1 41013 SEVILLA Zobacz na mapie Koszt całkowity Brak danych Birkbeck College, University of London Zjednoczone Królestwo Wkład UE Brak danych Adres Malet Street, Bloomsbury WC1E 7HX London Zobacz na mapie Koszt całkowity Brak danych
