Objetivo
Ageing is the single most important factor in the onset of disease in the European population. An understanding of the molecular and physiological mechanisms that cause ageing is essential for the rational intervention of age-related disease. Simple model systems that exhibit ageing provide and economical means to obtain this understanding. We shall determine the genes and physiological mechanisms that cause ageing in Caenorhabditis elegant with a view to targeting processes that underlie age-associated disease in humans. This will be achieved by an extensive, interdisciplinary analysis of a series of genetic variants that exhibit greatly slowed rates of ageing resulting in life span control ageing rate and 300% (Age mutants). This analysis will reveal both regulatory mechanisms that control ageing rate and downstream mechanisms that constitute the molecular and physiological causes of ageing. We predict that many of the mechanisms we uncover will be universally linked to ageing in all animals and that consequently the targeting of these mechanisms will ameliorate age-related disease or postpone its onset.
Convocatoria de propuestas
Data not availableRégimen de financiación
CSC - Cost-sharing contractsCoordinador
9000 GENT
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