Obiettivo Parkinson's disease (PD) is a neurodegenerative illness with high prevalence and long course characterized by severe motor and cognitive impairments. Clinical trials have recently shown that chronic high frequency stimulation (HFS) of sub thalamic nucleus (STN) alleviates Parkinson Ian motor symptoms and elodea-induced complications at advanced stages of PD. However, little is known about the functional mechanisms of this new therapeutically tool, its long-term motor effects and consequences on cognitive functions. The aim of this project is thus to address these issues. Behavioural consequences of STN HFS will be specified in terms of motor and cognitive functions in PD patients and in animal models. Biochemical and cellular events underlying the behavioural effects of STN HFS and neuropath logical factors that may govern its efficacy will be investigated in animal models. The results are expected to have major socio-economic impacts by improving indication of STN HFS in the course of PD. Campo scientifico natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologyparkinson Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Contributo UE Nessun dato Indirizzo Chemin Joseph Aiguier 31 13402 MARSEILLE Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto HUMBOLDT-UNIVERSITAET BERLIN Germania Contributo UE Nessun dato Indirizzo UNTER DEN LINDEN 9 10099 BERLIN Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo ADR 5 - Rhône-Alpes, Auvergne, Bourg. Univ. J.Fo 38043 GRENOBLE Mostra sulla mappa Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE Mostra sulla mappa Costo totale Nessun dato
