Objetivo This project aims at designing a new therapeutic approach for the restoration of sensory function after damage in the inner ear auditory and balance organs. This goal will be reached through the better understanding of the regenerative and "neo-synaptogenesis" potential of inner ear sensory neurons and on how this potential can be enhanced in vivo in hearing impaired animals. Stem cell lines from normal animals and form transgenic animals over expressing neurotrophic factors will be established and these cells will be further manipulated using genetic engineering. The ability of these cells to support regeneration in the inner ear will be assessed with functional in vitro and in vivo approaches. This cell therapy approach will be combined with existing biopolymer implants and with existing cochlear electrode prosthesis into a BIOELECTRODE implant. Ámbito científico medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesmedical biotechnologyimplants Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-9. - Neurosciences Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Aportación de la UE Sin datos Dirección Avenue du Fontaule 1 66651 BANYULS SUR MER Francia Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo KAROLINSKA INSTITUTE Suecia Aportación de la UE Sin datos Dirección Novum, KFC plan 4 141 86 STOCKHOLM Ver en el mapa Coste total Sin datos NATIONAL RESEARCH COUNCIL OF ITALY Italia Aportación de la UE Sin datos Dirección Via Vanvitelli 32 20129 MILANO Ver en el mapa Coste total Sin datos SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE Suiza Aportación de la UE Sin datos Dirección AAB 132 1015 LAUSANNE Ver en el mapa Coste total Sin datos
