Objective Diabetes is a major health problem in Europe. Limited availability of donor tissue restricts conventional transplant treatments. Therefore, we propose to bioengineer pancreatic islet microorgans (called pseudoislets) using glucose-responsive insulin-producing cells of differentiated stem cell origin. These microorgans should be suitable substitutes to restore the function of the destroyed pancreatic islets in a diabetic individual. The combination of the bioengineering of insulin-secreting surrogate cells with techniques for generation of a pancreatic islet microorgan represents a highly innovative experimental approach. This Cell Factory concept for an innovative insulin replacement therapy, applied to cells of human origin, can offer, due to the unlimited supply, a cure to many diabetic patients. The long-standing expertise and experience of the partners in this proposal bring together the capabilities to achieve this highly desirable goal. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator HANNOVER MEDICAL SCHOOL EU contribution No data Address CARL-NEUBERG-STRASSE 1 30625 HANNOVER Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CARDION AG Germany EU contribution No data Address Max-Planck-Str. 15a 40699 ERKRATH See on map Total cost No data UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Spain EU contribution No data Address Avenida del Ferrocarril s/n 03202 ELCHE See on map Total cost No data UNIVERSITE LIBRE DE BRUXELLES Belgium EU contribution No data Address Route de Lennik, 808 1070 BRUXELLES See on map Total cost No data UNIVERSITY OF ASTON United Kingdom EU contribution No data Address Aston Triangle B4 7ET BIRMINGHAM See on map Total cost No data UNIVERSITY OF GENEVA Switzerland EU contribution No data Address Rue Michel-Servet 1 1211 GENEVE See on map Total cost No data UNIVERSITY OF ULSTER United Kingdom EU contribution No data Address Cromore Road BT52 1SA COLERAINE See on map Total cost No data
