Objective
Diabetes is a major health problem in Europe. Limited availability of donor tissue restricts conventional transplant treatments. Therefore, we propose to bioengineer pancreatic islet microorgans (called pseudoislets) using glucose-responsive insulin-producing cells of differentiated stem cell origin. These microorgans should be suitable substitutes to restore the function of the destroyed pancreatic islets in a diabetic individual. The combination of the bioengineering of insulin-secreting surrogate cells with techniques for generation of a pancreatic islet microorgan represents a highly innovative experimental approach. This Cell Factory concept for an innovative insulin replacement therapy, applied to cells of human origin, can offer, due to the unlimited supply, a cure to many diabetic patients. The long-standing expertise and experience of the partners in this proposal bring together the capabilities to achieve this highly desirable goal.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
30625 HANNOVER
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.