Objectif ApoAI and apoB-100 are important apolipoproteins involved in cholesterol transport. Our specific aims are: 1) To identify the DNA binding proteins which recognize regulatory regions of human apoAI and apoB-100 genes and to define the binding domains and properties of these proteins. 2) To purify and characterize the nuclear proteins involved in transcritional activation of human apoAI and ApoB-100 genes. 3) To clone and sequence cDNAs encoding the protein factors involved in the transcriptional regulation of human apoAI and apoB-100 genes. 4) To express the cDNA clones encoding the transcriptional factors in vitro and in vivo and define the domains involved in DNA binding and transcriptional activation. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS Contribution de l’UE Aucune donnée Adresse Vassilika Vouton 71110 IRAKLION Grèce Voir sur la carte Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EUROPEAN MOLECULAR BIOLOGY LABORATORY Allemagne Contribution de l’UE Aucune donnée Adresse Meyerhofstrasse 1 HEIDELBERG Voir sur la carte Coût total Aucune donnée
