Objective BSE in sheep is currently considered as a major threat for the European ovine industry but also for human health. In this context, by federating the efforts of all major teams involved in sheep TSE in Europe, our proposal will help to:(I) Assess the BSE vertical and horizontal transmission in sheep under natural conditions.(ii) Determine the minimal infective BSE dose in sheep.(iii) Characterize consequences of multi passage in sheep on BSE strain phenotype and our ability to detect such an adapted strain.(iv) Evaluate strain detection in sheep in case of scrape/BSE co-infection, and so our ability to detect BSE in cc-infected BSE/scrapieflocks(v) Evaluate the effect of serial trans-species transmission on the species barrier, and more particularly on the human species barrier(vi) Confirm that the homozygous and heterozygous A_R_R_ sheep is not a TSE silent carriers" and better understand the cellular basis of this resistance. This project will bring new and definitive elements on the sensitive question of BSE in Sheep at both the animal and human health levels. Those data will be the basis for a scientifically based policy in BSE in sheep risk assessment. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE EU contribution No data Address Chemin des Capelles 23 31076 TOULOUSE France See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all CIDC-LELYSTAD, CENTRAAL INSTITUUT DIERZIEKTE CONTROLE LELYSTAD Netherlands EU contribution No data Address Houtribweg 39 8221 RA LELYSTAD See on map Total cost No data DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS United Kingdom EU contribution No data Address Woodham Lane, New Haw KT15 3NB ADDLESTONE See on map Total cost No data FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH Germany EU contribution No data Address Boddenblick 5 A 17498 INSEL RIEMS See on map Total cost No data INSTITUTE FOR ANIMAL HEALTH United Kingdom EU contribution No data Address Compton Laboratory, Compton RG20 7NN NEWBURY See on map Total cost No data INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA Spain EU contribution No data Address Carreteria de Algete a el Casar KM 8.1 s/n 28130 VALDEOLMOS - MADRID See on map Total cost No data National Veterinary Institute Norway EU contribution No data Address ULLEVAALSVEIEN 68 0106 OSLO See on map Links Website Opens in new window Total cost No data University College Dublin Ireland EU contribution No data Address Ballsbridge 4 DUBLIN See on map Total cost No data
