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European project to study bse strain in sheep

Objective

BSE in sheep is currently considered as a major threat for the European ovine industry but also for human health. In this context, by federating the efforts of all major teams involved in sheep TSE in Europe, our proposal will help to:
(I) Assess the BSE vertical and horizontal transmission in sheep under natural conditions.
(ii) Determine the minimal infective BSE dose in sheep.
(iii) Characterize consequences of multi passage in sheep on BSE strain phenotype and our ability to detect such an adapted strain.
(iv) Evaluate strain detection in sheep in case of scrape/BSE co-infection, and so our ability to detect BSE in cc-infected BSE/scrapieflocks
(v) Evaluate the effect of serial trans-species transmission on the species barrier, and more particularly on the human species barrier
(vi) Confirm that the homozygous and heterozygous A_R_R_ sheep is not a TSE silent carriers" and better understand the cellular basis of this resistance. This project will bring new and definitive elements on the sensitive question of BSE in Sheep at both the animal and human health levels. Those data will be the basis for a scientifically based policy in BSE in sheep risk assessment.

Call for proposal

Data not available

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
Chemin Des Capelles 23
31076 Toulouse
France

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Participants (7)

CIDC-LELYSTAD, CENTRAAL INSTITUUT DIERZIEKTE CONTROLE LELYSTAD
Netherlands
Address
Houtribweg 39
8221 RA Lelystad

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DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
Address
Woodham Lane, New Haw
KT15 3NB Addlestone

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FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
Germany
Address
Boddenblick 5 A
17498 Insel Riems

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INSTITUTE FOR ANIMAL HEALTH
United Kingdom
Address
Compton Laboratory, Compton
RG20 7NN Newbury

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INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA
Spain
Address
Carreteria De Algete A El Casar Km 8.1 S/n
28130 Valdeolmos - Madrid

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National Veterinary Institute
Norway
Address
Ullevaalsveien 68
0106 Oslo

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University College Dublin
Ireland
Address
Ballsbridge
4 Dublin

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