Objectif Clinical data from radiotherapy and experimental evidence obtained in vitro demonstrate the existence of inter-individual variation in response to ionising irradiation. The contribution of age, genetic polymorphism and environmental factors to these variations is still unknown. We propose to identify cellular phenotypes, related to individual radiosensitivity. This will permit the identification of involved functional and positional candidate genes, whose polymorphisms actually modulate individual radiosensitivity. The proposed approach is based on the exploitation of the unique GENEPI biological resource, the use of two recently validated, quantitative in vitro assays of radiosensitivity, and on the application of state-of-the-art gene expression profiling technology. Results of the study are intended to lead to the development of a predictive test for individual radiosensitivity, capable of identifying persons at risk. Champ scientifique natural sciencesbiological sciencesgenetics Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Thème(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN Contribution de l’UE Aucune donnée Adresse Rue Juliette Dodu 27 75010 PARIS France Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire BELGIAN NUCLEAR RESEARCH CENTRE Belgique Contribution de l’UE Aucune donnée Adresse Boeretang 200 2400 MOL Voir sur la carte Coût total Aucune donnée COMMISSARIAT A L'ENERGIE ATOMIQUE France Contribution de l’UE Aucune donnée Adresse Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES Voir sur la carte Coût total Aucune donnée