Cel Introduction of foreign nucleic acids into an organism induces frequently silencing of the homologous sequences. In some cases silencing is the result of a repression of transcription (transcriptional gene silencing or TGS). In other cases the silenced genes are transcribed but transcripts are nearly undetectable (post-transcriptional gene silencing or PIGS). Recent work has focused attention on double stranded RNA as a trigger for both TGS and PIGS (RNA silencing). So far RNA-mediated TGS has only been reported in plants, but PTGS-related phenomena have been described in plants, fungi and animals. Some results indicate that RNA silencing is a host defence system protecting organisms against parasitic sequences such as transposable elements and viruses. Given the importance of these sequences in the genomes, the elucidation of the mechanisms involved in their taming is a challenging question. One of the most exciting aspects of PIGS is that it seems that one common mechanism acts in diverse organisms, maybe in all eukaryotes, indicating that they are very important processes. The possibility that RNA-induced genome modifications (methylation, chromatin structure) are common to eukaryotes is still an open question, but the increasing detection of non-coding or antisense RNAs in epigenetic phenomena involving DNA or chromatin modifications (sex chromosome dosage compensation, imprinting) suggests widespread occurrence. The participants to this network have decided to join their efforts to elucidate by a combination of genetic and biochemical approaches the mechanisms underlying PTGS and RNA-mediated TGS in a variety of organisms (plants, fungi and animals), to determine the relationships between these two types silencing, the similarities and differences in the mechanisms of RNA silencing in various kingdoms and how they may be responsible for the protection of eukaryotes against the propagation of transposable elements and viruses. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Temat(-y) 1.4.1.-1.1. - Research Training Networks Zaproszenie do składania wniosków Data not available System finansowania NET - Research network contracts Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Wkład UE Brak danych Adres Rue de la Cardonille 141 34396 MONTPELLIER Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko GMI - GREGOR-MENDEL-INSTITUT FUER MOLEKULARE PFLANZENBIOLOGIE GMBH Austria Wkład UE Brak danych Adres Dr Ignaz-Seipel-Platz 2 1010 WIEN Zobacz na mapie Koszt całkowity Brak danych NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY Niderlandy Wkład UE Brak danych Adres 8,Uppsalalaan 8 3584 CT UTRECHT Zobacz na mapie Koszt całkowity Brak danych THE SAINSBURY LABORATORY Zjednoczone Królestwo Wkład UE Brak danych Adres Norwich Research Park, Colney Lane NR4 7UH NORWICH Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF EDINBURGH Zjednoczone Królestwo Wkład UE Brak danych Adres King's Building, Darwing Building, Mayfield Road EH9 3Jr EDINBURGH Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF ROME "LA SAPIENZA" Włochy Wkład UE Brak danych Adres Viale Regina Elena 324 00161 Roma Zobacz na mapie Koszt całkowity Brak danych