Objective The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDR is a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells, etc. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR. Our objectives are:- To characterize mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components).- To examine the role of novel Components of the DNA damage signal transduction pathway.- To characterize the downstream effects of DDR on DNA replication, chromatin structure and ubiquit in mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologycytologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Topic(s) 1.4.1.-1.1. - Research Training Networks Call for proposal Data not available Funding Scheme NET - Research network contracts Coordinator CANCER RESEARCH UK EU contribution No data Address Clare Hall Laboratories, Blanche Lane EN6 3LD POTTERS BAR United Kingdom See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all BEN GURION UNIVERSITY OF THE NEGEV Israel EU contribution No data Address 84105 BEER SHEVA See on map Total cost No data CANCER RESEARCH UK United Kingdom EU contribution No data Address Blanche Lane, Clare hall Laboratories EN6 3LD SOUTH MIMMS See on map Total cost No data ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address Dr. Molewaterplein 50 3000 DR ROTTERDAM See on map Total cost No data INSTITUT CURIE France EU contribution No data Address Rue d' Ulm 26 75248 PARIS See on map Total cost No data UNIVERSITY OF GENEVA Switzerland EU contribution No data Address 30,Quai Ernest Ausermet 30 1211 GENEVE See on map Total cost No data UNIVERSITY OF SUSSEX United Kingdom EU contribution No data Address Falmer BN1 9RR BRIGHTON / FALMER See on map Total cost No data UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA Italy EU contribution No data Address Piazza della Scienza 2 20126 MILANO See on map Total cost No data