Objetivo
The present proposal concerns the development of atropenantioselective localizations using an intermolecular Standing legation strategy. The study will be undertaken in the Homestead/Van Maureen group at the University of Amsterdam. This group has recently disclosed a novel strategy for the synthesis of medium-sized lactase, and is currently developing the use of the /nframolecular Standing legation in difficult localizations, towards an improved synthesis of several homo- and heterodetically closed cyclopeptides. Future work proposed herein will be dedicated to the particularly challenging stereo selective synthesis of cyclopeptides exhibiting atropisomerism. Striking examples of related bioactive products are RP 66453 (neurotensine receptor antagonist) and the glycol part of vancomycin (glycopeptides antibiotic)
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Convocatoria de propuestas
FP6-2002-MOBILITY-5
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Régimen de financiación
EIF - Marie Curie actions-Intra-European FellowshipsCoordinador
AMSTERDAM
Países Bajos