Objective The goal of this proposal is to establish the basic conditions for DNA-based biotechnology-biotechnology. The programme which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises:(1) the optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel;(2) the development of novel binding procedures of DNA to metal or semiconductor surfaces;(3) tailored modifications of DNA bloomers and assembly of complex DNA architectures as elements of biosensor devices;(4)high-resolution mapping of the metal/DNA interface;(5)the investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy;(6)the study of interfacial charge transfer using scanning tunnelling microscopy;(7)an assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations The strong impact expected of this joint effort rests on the combination of different synthetic approaches, on the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilized hybrids of DNA and its analogues and single molecules imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this so far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics. In terms of immediate exploitation this CIDNA project will rest on novel robustness structures and analogues. In more general terms of DNA-chip technology the programme will also assess the potential of (cheap and fast) electrochemical readout periphery. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencescondensed matter physicssoft matter physicsnatural sciencesphysical sciencesopticsmicroscopyconfocal microscopy Keywords DNA Nanotechnology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2002-3.4.1.2-1 - Interfaces between biological and non biological entities Call for proposal FP6-2002-NMP-1 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator TECHNISCHE UNIVERSITAET MUENCHEN EU contribution No data Address Arcisstrasse 21 MUENCHEN Germany See on map Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all COLLEGE DE FRANCE France EU contribution No data Address Place Marcelin Berthelot 11 PARIS See on map Total cost No data VYSOKA SKOLA CHEMICKO TECHNOLOGICKA V PRAZE Czechia EU contribution No data Address Technicka 5 PRAHA 6 See on map Total cost No data UNIVERSITAET BASEL Switzerland EU contribution No data Address Petersplatz 1 BASEL See on map Links Website Opens in new window Total cost No data MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Hofgartenstrasse 8 MUENCHEN See on map Total cost No data COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address 31-33 Rue de la Federation PARIS See on map Total cost No data DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution No data Address Anker Engelundsvej 1, Bygning 101A LYNGBY See on map Total cost No data EXIQON A/S Denmark EU contribution No data Address Bygstubben 9 VEDBAEK See on map Total cost No data INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY, ACAD. SCI. CZECH REP. Czechia EU contribution No data Address Flemingovp nam. 2 PRAGUE See on map Links Website Opens in new window Total cost No data SYDDANSK UNIVERSITET. Denmark EU contribution No data Address Campusvej 55 ODENSE M See on map Links Website Opens in new window Total cost No data