Objective
The goal of this proposal is to establish the basic conditions for DNA-based biotechnology-biotechnology. The programme which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises:
(1) the optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel;
(2) the development of novel binding procedures of DNA to metal or semiconductor surfaces;
(3) tailored modifications of DNA bloomers and assembly of complex DNA architectures as elements of biosensor devices;
(4)high-resolution mapping of the metal/DNA interface;
(5)the investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy;
(6)the study of interfacial charge transfer using scanning tunnelling microscopy;
(7)an assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations The strong impact expected of this joint effort rests on the combination of different synthetic approaches, on the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilized hybrids of DNA and its analogues and single molecules imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this so far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics. In terms of immediate exploitation this CIDNA project will rest on novel robustness structures and analogues. In more general terms of DNA-chip technology the programme will also assess the potential of (cheap and fast) electrochemical readout periphery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences condensed matter physics soft matter physics
- natural sciences physical sciences optics microscopy confocal microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-NMP-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.