Obiettivo Bone is among the most frequently transplanted tissues and autography account for the majority of bone graft procedures. However, auto grafts always require a secondary surgery adding high costs to health services increase patient morbidity and are available in very limited quantities. Therefore, there is widespread interest around the world for programmes to rebuild and restore function of degenerative tissue using artificial implant materials. The enormous need for bone grafts and the recent progresses in biomedical and biomaterial sciences have stimulated the rapid growth and expansion of a new field: bone tissue engineering. However, this approach presents important limits to the transfer from an academic to a routine clinical environment: high cost, difficulties in transferring biological samples between hospitals and centralized "cell factories"; reproducibility due to lack of standards. The aim of this project is to combine the developments in the areas of tissue engineering based on materials and 3D scaffolds development with largely laboratory and few commercial activities in the field of bioreactors and transpose the concepts of tissue engineering and regeneration of the frontiers of new developments: the automated production of antilogous bone replacement materials The goal of this project is to develop a bioreactor that would be set-up within the confines oaf hospital and which would be used to homogenously activate specially designed porous matrices with stem cells from harvested bone marrow aspirates of the patient to produce antilogous hybrid bone graftmaterials.This target will be achieved through the following scientific and technical objectives:1) design and production of innovative bioreactors,2) design and production of novel biomaterials and scaffolds architectures tailored for both bioreactor use and bone tissue engineering,3) validation of the approach in preclinical animal studies. Campo scientifico engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplantsartificial bone Parole chiave Bioreactor Osteoinductive bone Tissue engineering Programma(i) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Argomento(i) NMP-2002-3.4.4.2 - Tissue engineering, new biomimetic and bio-hybrid systems Invito a presentare proposte FP6-2002-NMP-1 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore CONSIGLIO NAZIONALE DELLE RICERCHE Contributo UE Nessun dato Indirizzo Piazzale Aldo Moro 7 ROMA Italia Mostra sulla mappa Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto DANSK TEKNOLOGISK INSTITUT Danimarca Contributo UE Nessun dato Indirizzo Gregersensvej TAASTRUP Mostra sulla mappa Costo totale Nessun dato FIN-CERAMICA FAENZA S.R.L. Italia Contributo UE Nessun dato Indirizzo Via Granarolo 102 FAENZA Mostra sulla mappa Costo totale Nessun dato FUNDACION TEKNIKER Spagna Contributo UE Nessun dato Indirizzo Avenida Otaola 20 EIBAR Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE Francia Contributo UE Nessun dato Indirizzo Allee Emile Monso, 6 TOULOUSE Mostra sulla mappa Costo totale Nessun dato JOHANNES GUTENBERG UNIVERSITAET MAINZ Germania Contributo UE Nessun dato Indirizzo Saarstrasse 21 MAINZ Mostra sulla mappa Costo totale Nessun dato LABORATOIRE D'EVALUATION DES MATERIELS IMPLANTABLES SA Francia Contributo UE Nessun dato Indirizzo Technopole Montesquieu MARTILLAC Mostra sulla mappa Costo totale Nessun dato MILLENIUM BIOLOGIX AG Svizzera Contributo UE Nessun dato Indirizzo Wagistrasse 23 SCHLIEREN-ZURICH Mostra sulla mappa Costo totale Nessun dato ODENSE UNIVERSITETSHOSPITAL Danimarca Contributo UE Nessun dato Indirizzo Sdr. Boulevard 29 ODENSE Mostra sulla mappa Costo totale Nessun dato PRESENS PRECISION SENSING GMBH Germania Contributo UE Nessun dato Indirizzo Josef Engert Strasse 9 REGENSBURG Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI GENOVA Italia Contributo UE Nessun dato Indirizzo Via Balbi 5 GENOVA Mostra sulla mappa Costo totale Nessun dato UNIVERSITAET BASEL Svizzera Contributo UE Nessun dato Indirizzo Petersplatz 1 BASEL Mostra sulla mappa Costo totale Nessun dato