Obiettivo
Bone is among the most frequently transplanted tissues and autography account for the majority of bone graft procedures. However, auto grafts always require a secondary surgery adding high costs to health services increase patient morbidity and are available in very limited quantities. Therefore, there is widespread interest around the world for programmes to rebuild and restore function of degenerative tissue using artificial implant materials. The enormous need for bone grafts and the recent progresses in biomedical and biomaterial sciences have stimulated the rapid growth and expansion of a new field: bone tissue engineering. However, this approach presents important limits to the transfer from an academic to a routine clinical environment: high cost, difficulties in transferring biological samples between hospitals and centralized "cell factories"; reproducibility due to lack of standards. The aim of this project is to combine the developments in the areas of tissue engineering based on materials and 3D scaffolds development with largely laboratory and few commercial activities in the field of bioreactors and transpose the concepts of tissue engineering and regeneration of the frontiers of new developments: the automated production of antilogous bone replacement materials The goal of this project is to develop a bioreactor that would be set-up within the confines oaf hospital and which would be used to homogenously activate specially designed porous matrices with stem cells from harvested bone marrow aspirates of the patient to produce antilogous hybrid bone graftmaterials.This target will be achieved through the following scientific and technical objectives:
1) design and production of innovative bioreactors,
2) design and production of novel biomaterials and scaffolds architectures tailored for both bioreactor use and bone tissue engineering,
3) validation of the approach in preclinical animal studies.
Campo scientifico
- engineering and technologyenvironmental biotechnologybioremediationbioreactors
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplantsartificial bone
Parole chiave
Invito a presentare proposte
FP6-2002-NMP-1
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Meccanismo di finanziamento
STREP - Specific Targeted Research ProjectCoordinatore
ROMA
Italia