Cel Myocardial infarction (Ml) is an irreversible injury where sudden interruption of blood flow caused by the occlusion of an artery leads quickly to cardiac myocytes death, loss of tissue and scar formation. Since the self- renewal ability of adult cardiac myocytes is limited, the development of strategies to regenerate damaged myocardium and improve its function represents a major challenge in the treatment of cardiac diseases. Recent evidences have suggested that multipotent somatic stem cells can become reprogrammed in new tissue-specific stem cell niches. However, despite the growing number of observations reporting "trans-differentiation" of adult tissue-derived stem cells, there are no conclusive evidences on the mechanism(s) underlying changes in stem cell fate and sufficient information on the therapeutic potential of these cells. In this proposal we aim to provide a contribution on validation of the use of adult tissue derived stem cells for myocardial repair by: 1) identifying the most suitable adult stem cell type(s) to be used to promote myocardial repair/regeneration; 2) unraveling the combination of stimuli that might drive differentiation of stem cells toward a cardiac myocyte lineage; 3) define genes and factors driving stem cell differentiation into cardiac lineage and set-up safe and effective vectors and protocols to induce cardiac myocyte differentiation pathway(s) by gene transfer; 4) assessing the functional properties of stem cell-derived cardiac myocytes; 5) unraveling the action of factors that might be involved in recruitment and homing of endogenous stem cell in myocardium; 6) evaluating the mid- and long-term effects of stem cell administration by clinical trials of autologous hematopoietic stem cell administration in patients suffering ischemic heart disease. Dziedzina nauki medical and health scienceshealth sciencespublic healthsocial sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinecardiology Słowa kluczowe gene transfer genomic analysis myocardial infarction stem cell tissue regeneration Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2002-1.2.4-5 - Stem cell products for myocardial repair Zaproszenie do składania wniosków FP6-2002-LIFESCIHEALTH Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELL'IMMACOLATA CONCEZIONE Wkład UE Brak danych Adres Via dei Monti di Creta, 104 ROME Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (9) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CENTRO CARDIOLOGICO MONZINO, I.R.C.C.S. Włochy Wkład UE Brak danych Adres Via Parea, 4 MILAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE JAGIELLONIAN UNIVERSITY, MEDICAL COLLEGE Polska Wkład UE Brak danych Adres Sw. Anny 12 KRAKÓW Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUTE OF PLANT GENETICS AND CROP PLANT RESEARCH Niemcy Wkład UE Brak danych Adres Correntstr. 3 GATERSLEBEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NL Niderlandy Wkład UE Brak danych Adres UTRECHT Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EUROPEAN MOLECULAR BIOLOGY LABORATORY Włochy Wkład UE Brak danych Adres Via Ramarini, 32 MONTEROTONDO SCALO (RM) Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ARETA INTERNATIONAL Włochy Wkład UE Brak danych Adres Viale Regina Giovanna, 17 MILAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych LUDWIGS-MAXIMILIANS-UNIVERSITAET MUENCHEN Niemcy Wkład UE Brak danych Adres Geschwister-Scholl-Platz 1 MUNICH Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT FÜR POLYMERFORSCHUNG DRESDEN E. V., DEPT. BIOKOMPATIBLE MATERIALIEN Niemcy Wkład UE Brak danych Adres Hohe Str.6 DRESDEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITÀ DEGLI STUDI MILANO-BICOCCA Włochy Wkład UE Brak danych Adres P.za dell'Ateneo Nuovo, 1 MILAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
