Obiettivo In response to urgent medical and societal needs for novel immunotherapies for cancer and chronic infections and for prophylactic vaccination, optimised delivery systems for vaccine targeting to dendritic cells will be developed and clinically evaluated. The approach will rely on two new antigen delivery vectors, the detoxified adenylate cyclase toxoid (ACT) and the porcine parvovirus-like particles (PPV-VLP) which were recently shown to target dendritic cells very efficiently and specifically, allowing highly efficient presentation of delivered antigens to T cells. These vaccine vectors enable the induction of strong, specific and protective immune responses and have an established record of safety and efficacy in preclinical animal models. Under this project, academia experts in immunology, vaccinology, molecular biology and structural biology have joined forces with toxicologists, clinicians and vaccine production experts of two companies, in order to translate these novel vaccine technologies from research into clinical application. Based on the preclinical record of ACT-based vaccines in animal models, the leap into safety and efficacy Phase l/ll human clinical trial will be made with an ACT-based construct delivering the tyrosinase A.2 epitope as a therapeutic vaccine for metastasic melanoma.Simultaneously to GMP batch production, development and clinical testing, in-depth analysis of the cellular and molecular mechanisms and of the structural basis of ACT interaction with dendritic cells will be conducted, by placing particular emphasis on gaining new knowledge for further improvement of the delivery capacity of the ACT molecule towards enhanced efficiency and broader versatility in clinical use. The PPV-VLP vector will be developed in parallel by defining its cellular receptor and trafficking inside dendritic cells,preclinical efficacy and toxicology, in order to bring this alternative vaccine carrier to the level of clinic. Campo scientifico medical and health sciencesclinical medicineoncologyskin cancermelanomamedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesbasic medicinetoxicologynatural sciencesbiological sciencesmolecular biologystructural biology Parole chiave Cancer vaccine Dendritic cell targeting Molecular basis for DC targeting Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-1.2.4-6 - Development of vaccine technologies targeted to dendritic cells Invito a presentare proposte FP6-2002-LIFESCIHEALTH Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore INSTITUT PASTEUR Contributo UE Nessun dato Indirizzo 25 rue du Docteur ROUX PARIS Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo 3, rue Michel-Ange PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato IMMUNOLOGIA Y GENETICA APLICADA S.A. Spagna Contributo UE Nessun dato Indirizzo C/HNOS GARCIA NOBLEJAS 41 MADRID Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTE OF MICROBIOLOGY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Cechia Contributo UE Nessun dato Indirizzo Videnska 1083 PRAGUE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY Belgio Contributo UE Nessun dato Indirizzo 75, Avenue Hippocrate UCL 7550 BRUXELLES Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NATIONAL BIOLOGICAL STANDARDS BOARD Regno Unito Contributo UE Nessun dato Indirizzo Blanche Lane, South Mimms POTTERS BAR Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
