Obiettivo The RETHINK project will produce an impact assessment report on toxicity testing in the mini-pig as an alternative approach that can contribute to the replacement, refinement and reduction of animal testing (3Rs). The pig is close to man in terms of ana tomy, physiology and biochemistry and in consequence is an attractive model for safety evaluation and biomedical research, which may permit the replacement of dogs and monkeys and the more efficient and predictive use of biological resources and animal l ife. This promising approach is deserving of objective evaluation and this is the propitious moment, as legislation places greater emphasis on alternative approaches in safety evaluation (eg REACH initiative), and as toxicogenomics begins to make a cont ribution to safety issues. If the minipig is to provide a valid, realistic and robust alternative approach for use in the regulatory testing of new medicines and chemicals, while contributing to the 3Rs, there are issues that must be addressed in six div erse areas: (i) animal welfare, (ii) ethics, (iii) new medicines and chemicals development, (iv) validation of animals models in safety evaluation, (v) genomics and emerging technologies, and (vi) economic impact and overview issues. The Steering G roup (SG) of consortium members will assemble Working Groups (WG¿s) of recognised experts in each topic area and will provide WG¿s with methods to define a hierarchy of issues and develop responses. WG¿s will review and summarise the available body of kn owledge for their topic and prepare conclusions and recommendations, including identification of gaps in knowledge where further research is required, and technical gaps presenting obstacles to the use of minipigs. The WG documents will be finalised for a plenary meeting of experts, followed by editing into the final Impact Assessment report. The Impact Assessment will be made publicly available and disseminated to relevant stakeholders Campo scientifico natural sciencesbiological sciencesbiochemistrymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsagricultural sciencesanimal and dairy sciencedomestic animalsmedical and health sciencesbasic medicinephysiologymedical and health sciencesbasic medicinetoxicology Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2004-1.2.3-5 - Mini-pigs as models for toxicity testing of new drugs and chemicals: impact assessment Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento SSA - Specific Support Action Coordinatore CENTRE INTERNATIONAL DE TOXICOLOGIE Contributo UE Nessun dato Indirizzo Miserey EVREUX Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ELLEGAARD GOTTINGEN MINIPIGS APS Danimarca Contributo UE Nessun dato Indirizzo SOROE LANDEVEJ 302 DALMOSE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato RIJKSINSTITUUT VOOR VOLKSGEZONDHEIT EN MILIEU Paesi Bassi Contributo UE Nessun dato Indirizzo Antonie van Leeuwenhoeklaan, 9 BILTHOVEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato