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ACGT

Project ID: 026996
Funded under

Advancing Clinico-Genomic Trials on Cancer: Open Grid Services for Improving Medical Knowledge Discovery

From 2006-02-01 to 2010-07-31, closed project | ACGT Website

Project details

Total cost:

EUR 16 652 261

EU contribution:

EUR 11 887 000

Coordinated in:

France

Call for proposal:

FP6-2004-IST-4See other projects for this call

Funding scheme:

IP - Integrated Project

Description

Harnessing grid computing to fight disease

A future in which patients receive personalised treatment based on their genetic make-up is fast becoming a reality.

But the genomic and clinical techniques that makes personalised healthcare possible has left researchers wallowing in reams of medical data. Far too often, the amount of data they have gathered surpasses their ability to analyse the information and put it to good use.

To help overcome the information overload problem, the ACGT project has successfully created a computerised system to organise such data, opening the way for the medical sector to deliver more personalised services to patients and ultimately improve health care.

By making the process of data analysis faster and more efficient, ACGT’s system permits even more rapid advances in developing treatments for a variety of diseases.

Focusing on information gathered in clinical and genomic trials involving cancer patients, the ACGT researchers developed a technical infrastructure to support the efficient sharing of such knowledge.

Drugs fine-tuned to your genes

For example, such a system would help doctors to rapidly identify what form of treatment best suits which patient, even permitting drugs to be quickly developed that are fine-tuned to their needs.

Such personalised treatment promises to give doctors a better chance of giving patients the correct medication for their condition, as well as developing treatment plans in such a way that drug side effects and other complications are minimised.

Sharing and analysing data on the grid

The backbone of the infrastructure is grid computing, which harnesses the resources of multiple, dispersed computers to gather, analyse and share data.

The project’s biomedical grid infrastructure specifically allows doctors to identify cancer profiles and best treatments rapidly, although it could be used for any disease, or for research and trials.

In addition to creating the grid infrastructure, the ACGT team also developed new methods for cross-referencing medical terms and their biological contexts. They also created common standards for storing medical research information at each level of investigation.

In doing so, they addressed issues related to data sharing, including the legal and regulatory aspects.

Tested in clinical trials

Their system allows doctors to compare accurately the results of different clinical trials and lets researchers more rapidly search for information from multiple sources.

The project partners are currently using the system in clinical trials involving patients suffering from breast cancer and paediatric nephroblastoma, a rare kind of kidney cancer that affects children and is also known as Wilms’ tumour.

Their goal is to improve further upon the results obtained so far from the combination of clinical and genetic information, which in the case of treating paediatric nephroblastoma has resulted in a success rate of up to 85%.

Objective

The completion of the Human Genome Project sparked the development of many new tools for today¿s biomedical researcher to use in finding the mechanism behind disease. While the goal is clear, the path to such discoveries has been fraught with roadblocks in terms of technical, scientific, and sociological challenges.ACGT brings together internationally recognised leaders in their respective fields, with the aim to deliver to the cancer research community an integrated Clinico-Genomic ICT environment enabled by a powerful GRID infrastructure. In achieving this objective ACGT has formulated a coherent, integrated workplan for the design, development, integration and validation of all technologically challenging areas of work. Namely: (a) GRID: delivery of a European Biomedical GRID infrastructure offering seamless mediation services for sharing data and data-processing methods and tools, and advanced security; (b) Integration: semantic, ontology based integration of clinical and genomic/proteomic data - taking into account standard clinical and genomic ontologies and metadata; (c) Knowledge Discovery: Delivery of data-mining GRID services in order to support and improve complex knowledge discovery processes.The technological platform will be validated in concrete setting of advanced clinical trials on Cancer. Pilot trials have been selected based on the presence of clear research objectives, raising the need to integrate data at all levels of the human being.ACGT promotes the principle of open source and open access, thus enabling the gradual creation of a European Biomedical Grid on Cancer. Hence, the project plans to introduce additional clinical trials during its lifecycle. It is in line with EU priorities and the objectives of the IST program. It targets the fulfilment of urgent needs of the cancer research community, a key area of societal importance and with a view to strengthening the integration of the European Research Area.

Related information

Documents and Publications

Coordinator contact

Jessica MICHEL, (European Relations Manager)
Tel.: +33 4 92 38 50 12
Fax: +33 4 92 38 50 11
E-mail

Coordinator

GEIE ERCIM
France

EU contribution: EUR 665 267


ROUTE DES LUCIOLES 2004 SOPHIA ANTIPOLIS
06410 BIOT
France
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: JESSICA MICHEL
Tel.: 33492385089
Fax: 33492385011
E-mail

Participants

ASSOCIATION HOSPITALIERE DE BRUXELLES - CENTRE HOSPITALIER UNIVERSITAIRE BORDET - ASSOCIATION DE DROIT PUBLIC ASBL
Belgium

EU contribution: EUR 556 316


RUE HEGER BORDET 1
1000 BRUXELLES
Belgium
Activity type: Other
Administrative contact: Christos Sotiriou
Tel.: +32 2 541 3428
Fax: +32 2 5380858
E-mail
UNIVERSITE DE NAMUR ASBL
Belgium

EU contribution: EUR 280 476


RUE DE BRUXELLES 61
5000 NAMUR
Belgium
Activity type: Higher or Secondary Education Establishments
Administrative contact: Yves POULLET
Tel.: 3281724779
Fax: 3281725202
E-mail
SWISS INSTITUTE OF BIOINFORMATICS
Switzerland

EU contribution: EUR 448 921


Rue Michel Servet 1
1211 GENEVE
Switzerland
Activity type: Research Organisations
Administrative contact: Mauro Delorenzi
Tel.: +41216924050
Fax: +41216924055
E-mail
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany

EU contribution: EUR 287 578


Welfengarten 1
30167 HANNOVER
Germany
Activity type: Higher or Secondary Education Establishments
Administrative contact: Nikolaus Forgó
Tel.: 49 511 762 8159
Fax: 49 511 762 8290
E-mail
UNIVERSITAT DES SAARLANDES
Germany

EU contribution: EUR 731 334


CAMPUS
66123 SAARBRUCKEN
Germany
Activity type: Higher or Secondary Education Establishments
Administrative contact: Norbert Graf
Tel.: 004968411628397
Fax: 004968411628302
E-mail
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany

EU contribution: EUR 941 128


HANSASTRASSE 27C
80686 MUNCHEN
Germany
Activity type: Research Organisations
Administrative contact: Michael May
Tel.: +49-2241-142039
Fax: +49-2241-142072
E-mail
UNIVERSITAET HAMBURG
Germany

EU contribution: EUR 243 613


MITTELWEG 177
20148 HAMBURG
Germany
Activity type: Higher or Secondary Education Establishments
Administrative contact: Regine Kollek
Tel.: +49-40428036309
Fax: +49-40428036315
E-mail
UNIVERSIDAD DE MALAGA
Spain

EU contribution: EUR 391 379


CALLE EL EJIDO S/N
29013 MALAGA
Spain
Activity type: Higher or Secondary Education Establishments
Administrative contact: Oswaldo Trelles Salazar
Tel.: +(34) 952132823
Fax: +(34)952132790
E-mail
UNIVERSIDAD POLITECNICA DE MADRID
Spain

EU contribution: EUR 593 792


CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO
28040 MADRID
Spain
Activity type: Higher or Secondary Education Establishments
Administrative contact: Victor Maojo
Tel.: +34913366897
Fax: +34913524819
E-mail
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE
France

EU contribution: EUR 364 097


DOMAINE DE VOLUCEAU
78153 LE CHESNAY
France
Administrative contact: Jacques Nicolas
Tel.: 33299847312
Fax: 33299847171
E-mail
HEALTHGRID
France

EU contribution: EUR 342 774


Rue Charles de Montesquieu 36
63430 PONT DU CHATEAU
France
Activity type: Other
Administrative contact: Yannick LEGRE
Tel.: +33 473 405 155
Fax: +33 473 405 001
E-mail
FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS
Greece

EU contribution: EUR 979 701


N PLASTIRA STR 100
70013 HERAKLION
Greece
Activity type: Research Organisations
Administrative contact: Manolis Tsiknakis
Tel.: +30 2810 391690
Fax: +30 2810 391428
E-mail
INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS
Greece

EU contribution: EUR 463 152


Patission Str. 42
10682 ATHINA
Greece
Activity type: Research Organisations
Administrative contact: Georgios Stamatakos
Tel.: (+30)2107722288
Fax: (+30)2107723557
E-mail
A. PERSIDIS & SIA OE
Greece

EU contribution: EUR 441 149


RODOPOLEOS STREET 34
16777 ATHINA
Greece
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: ANDREAS PERSIDIS
Tel.: 302109629848
Fax: 302109647606
E-mail
PANEPISTIMIO KRITIS
Greece

EU contribution: EUR 201 778


UNIVERSITY CAMPUS GALLOS
74100 RETHIMNO
Greece
Activity type: Higher or Secondary Education Establishments
Administrative contact: Eelco De Bree
Tel.: +30 2810 392056
Fax: +30 2810 392382
E-mail
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy

EU contribution: EUR 243 008


Via Filodrammatici 10
20121 MILANO
Italy
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Gordon MacVie
Tel.: +39-0257489816
Fax: +39-0257489922
E-mail
HOKKAIDO UNIVERSITY
Japan

EU contribution: EUR 0


KITA 8 NISHI 5 KITA KU
060 0808 SAPPORO
Japan
Activity type: Higher or Secondary Education Establishments
Administrative contact: Yuzuru Tanaka
Tel.: +81 11 706 7250
Fax: +81 11 706 7808
UNIVERSITEIT VAN AMSTERDAM
Netherlands

EU contribution: EUR 518 163


SPUI 21
1012WX AMSTERDAM
Netherlands
Activity type: Higher or Secondary Education Establishments
Administrative contact: Peter Sloot
Tel.: +31 20 525 7462
Fax: +31 20 525 7419
E-mail
PHILIPS ELECTRONICS NEDERLAND B.V.
Netherlands

EU contribution: EUR 935 328


BOSCHDIJK 525
5621 JG EINDHOVEN
Netherlands
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Anca Bucur
Tel.: +31 40 2744609
Fax: +31 40 2743741
E-mail
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Poland

EU contribution: EUR 597 219


NOSKOWSKIEGO 12-14
61704 POZNAN
Poland
Activity type: Other
Administrative contact: Jaroslaw Nabrzyski
Tel.: +48 61 858 2072
Fax: +48 61 852 5954
E-mail
SIVECO ROMANIA SA
Romania

EU contribution: EUR 278 195


SOSEAUA BUCURESTI-PLOIESTI COMPLEX VICTORIA PARK CORP CLADIRE C4 SECTOR 1 73-81
013685 BUCURESTI
Romania
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: OTTO ZELCH
Tel.: +40 21 318 1200
Fax: +40 21 318 1202
E-mail
LUNDS UNIVERSITET
Sweden

EU contribution: EUR 471 279


Paradisgatan 5c
22100 LUND
Sweden
Activity type: Higher or Secondary Education Establishments
Administrative contact: Carsten Peterson
Tel.: +46 46 222 9002
Fax: +46 46 222 9686
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

EU contribution: EUR 458 899


WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD OXFORD
United Kingdom
Activity type: Higher or Secondary Education Establishments
Administrative contact: Adrian L Harris
Tel.: +44 1865 226184
Fax: +44 1865 226159
E-mail
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

EU contribution: EUR 0


RUE MICHEL ANGE 3
75794 PARIS
France
Activity type: Research Organisations
INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE
France

EU contribution: EUR 0


DOMAINE DE VOLUCEAU ROCQUENCOURT
78153 LE CHESNAY CEDEX
France
Activity type: Research Organisations
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES
France

EU contribution: EUR 0


AVENUE DES BUTTES DE COESMES 20
35708 RENNES CEDEX 7
France
Activity type: Higher or Secondary Education Establishments
UNIVERSITE DE RENNES I
France

EU contribution: EUR 0


RUE DU THABOR 2
35065 RENNES CEDEX
France
Activity type: Higher or Secondary Education Establishments
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