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Advancing Clinico-Genomic Trials on Cancer: Open Grid Services for Improving Medical Knowledge Discovery

Project description

Integrated biomedical information for better health Harnessing grid computing to fight disease

A future in which patients receive personalised treatment based on their genetic make-up is fast becoming a reality.

But the genomic and clinical techniques that makes personalised healthcare possible has left researchers wallowing in reams of medical data. Far too often, the amount of data they have gathered surpasses their ability to analyse the information and put it to good use.

To help overcome the information overload problem, the ACGT project has successfully created a computerised system to organise such data, opening the way for the medical sector to deliver more personalised services to patients and ultimately improve health care.

By making the process of data analysis faster and more efficient, ACGT’s system permits even more rapid advances in developing treatments for a variety of diseases.

Focusing on information gathered in clinical and genomic trials involving cancer patients, the ACGT researchers developed a technical infrastructure to support the efficient sharing of such knowledge.

Drugs fine-tuned to your genes

For example, such a system would help doctors to rapidly identify what form of treatment best suits which patient, even permitting drugs to be quickly developed that are fine-tuned to their needs.

Such personalised treatment promises to give doctors a better chance of giving patients the correct medication for their condition, as well as developing treatment plans in such a way that drug side effects and other complications are minimised.

Sharing and analysing data on the grid

The backbone of the infrastructure is grid computing, which harnesses the resources of multiple, dispersed computers to gather, analyse and share data.

The project’s biomedical grid infrastructure specifically allows doctors to identify cancer profiles and best treatments rapidly, although it could be used for any disease, or for research and trials.

In addition to creating the grid infrastructure, the ACGT team also developed new methods for cross-referencing medical terms and their biological contexts. They also created common standards for storing medical research information at each level of investigation.

In doing so, they addressed issues related to data sharing, including the legal and regulatory aspects.

Tested in clinical trials

Their system allows doctors to compare accurately the results of different clinical trials and lets researchers more rapidly search for information from multiple sources.

The project partners are currently using the system in clinical trials involving patients suffering from breast cancer and paediatric nephroblastoma, a rare kind of kidney cancer that affects children and is also known as Wilms’ tumour.

Their goal is to improve further upon the results obtained so far from the combination of clinical and genetic information, which in the case of treating paediatric nephroblastoma has resulted in a success rate of up to 85%.

Call for proposal

FP6-2004-IST-4
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

GEIE ERCIM
Address
Route Des Lucioles 2004 Sophia Antipolis
06410 Biot
France
Activity type
Other
EU contribution
€ 665 267

Participants (27)

ASSOCIATION HOSPITALIERE DE BRUXELLES - CENTRE HOSPITALIER UNIVERSITAIRE BORDET - ASSOCIATION DE DROIT PUBLIC ASBL
Belgium
EU contribution
€ 556 316
Address
Rue Heger Bordet 1
1000 Bruxelles
Activity type
Other
UNIVERSITE DE NAMUR ASBL
Belgium
EU contribution
€ 280 476
Address
Rue De Bruxelles 61
5000 Namur
Activity type
Higher or Secondary Education Establishments
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 448 921
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany
EU contribution
€ 287 578
Address
Welfengarten 1
30167 Hannover
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 731 334
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 941 128
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
UNIVERSITAET HAMBURG
Germany
EU contribution
€ 243 613
Address
Mittelweg 177
20148 Hamburg
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE MALAGA
Spain
EU contribution
€ 391 379
Address
Avda Cervantes, Num. 2
29016 Malaga
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD POLITECNICA DE MADRID
Spain
EU contribution
€ 593 792
Address
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE
France
EU contribution
€ 364 097
Address
Domaine De Voluceau
78153 Le Chesnay
HEALTHGRID
France
EU contribution
€ 342 774
Address
Rue Charles De Montesquieu 36
63430 Pont Du Chateau
Activity type
Other
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 979 701
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS
Greece
EU contribution
€ 463 152
Address
Patission Str. 42
10682 Athina
Activity type
Research Organisations
A. PERSIDIS & SIA OE
Greece
EU contribution
€ 441 149
Address
Rodopoleos Street 34
167 77 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANEPISTIMIO KRITIS
Greece
EU contribution
€ 201 778
Address
University Campus Gallos
74100 Rethimno
Activity type
Higher or Secondary Education Establishments
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 243 008
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOKKAIDO UNIVERSITY
Japan
EU contribution
€ 0
Address
Kita 8 Nishi 5 Kita Ku
060 0808 Sapporo
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 518 163
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
EU contribution
€ 935 328
Address
High Tech Campus 52
5656 AG Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 597 219
Address
Noskowskiego 12-14
61 704 Poznan
Activity type
Research Organisations
SIVECO ROMANIA SA
Romania
EU contribution
€ 278 195
Address
Soseaua Bucuresti-ploiesti 73-81 Complex Victoria Park Corp Cladire C4 Sector 1
013685 Bucuresti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 471 279
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 458 899
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 0
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE
France
EU contribution
€ 0
Address
Domaine De Voluceau Rocquencourt
78153 Le Chesnay Cedex
Activity type
Research Organisations
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES
France
EU contribution
€ 0
Address
Avenue Des Buttes De Coesmes 20
35708 Rennes Cedex 7
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE RENNES I
France
EU contribution
€ 0
Address
Rue Du Thabor 2
35065 Rennes Cedex
Activity type
Higher or Secondary Education Establishments