Objective
NDL-PCBs are poorly characterised from a toxicological point of view, and to date, there is no health risk assessment available. Since NDL-PCBs constitute a major part of the PCBs found in food and human tissues it has become an urgent matter to advance the understanding of their toxicity. The topic has recently been discussed in several organisations, which provide advice to the regulators. Neurobehavioural, reproductive and developmental toxicity, and tumour promotion have been pointed out by the European commission to be of particular concern. The present project proposal ATHON addresses all of these effects, as well as indicators for immunotoxicity, endocrine disturbances, general liver toxicity, and NDL-PCB metabolism. Studies will be designed to meet the quantitative and qualitative requirements on toxicological data for use in the hazard assessment procedures. Efforts will be made to identify toxicological mechanisms and outcomes, specific for NDL-PCBs. Such knowledge is a prerequisite for future meaningful studies of NDL-PCB epidemiology. The major objectives are to: 1) establish quality-controlled experimental in vivo and in vitro models for studies of NDL-PCBs 2) provide toxicokinetic data of for NDL-PCBs 3) provide quantitative and qualitative toxicity profiles for NDL-PCBs 4) provide a new classification strategy for NDL-PCB congeners based on effect biomarker information 5) provide an up-to-date compilation and evaluation of toxicological effect and exposure data on NDL-PCBs and PCB metabolites A multidisciplinary approach is required to achieve the objectives, and a consortium with a wide range of expertise has been established. Non-EU partners, project collaborators, and an international advisory board are involved to meet the international dimension of the problem. Clearly, with this approach ATHON will provide missing critical health hazard information and clarify biological mechanisms underlying the various types of toxicity induced by NDL-PCBs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health epidemiology
- agricultural sciences animal and dairy science dairy
- social sciences sociology governance crisis management
- medical and health sciences clinical medicine endocrinology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-FOOD-3-B
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.