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Assessing the Toxicity and Hazard of Non-dioxin-like PCBs present in food

Objective

NDL-PCBs are poorly characterised from a toxicological point of view, and to date, there is no health risk assessment available. Since NDL-PCBs constitute a major part of the PCBs found in food and human tissues it has become an urgent matter to advance the understanding of their toxicity. The topic has recently been discussed in several organisations, which provide advice to the regulators. Neurobehavioural, reproductive and developmental toxicity, and tumour promotion have been pointed out by the European commission to be of particular concern. The present project proposal ATHON addresses all of these effects, as well as indicators for immunotoxicity, endocrine disturbances, general liver toxicity, and NDL-PCB metabolism. Studies will be designed to meet the quantitative and qualitative requirements on toxicological data for use in the hazard assessment procedures. Efforts will be made to identify toxicological mechanisms and outcomes, specific for NDL-PCBs. Such knowledge is a prerequisite for future meaningful studies of NDL-PCB epidemiology. The major objectives are to: 1) establish quality-controlled experimental in vivo and in vitro models for studies of NDL-PCBs 2) provide toxicokinetic data of for NDL-PCBs 3) provide quantitative and qualitative toxicity profiles for NDL-PCBs 4) provide a new classification strategy for NDL-PCB congeners based on effect biomarker information 5) provide an up-to-date compilation and evaluation of toxicological effect and exposure data on NDL-PCBs and PCB metabolites A multidisciplinary approach is required to achieve the objectives, and a consortium with a wide range of expertise has been established. Non-EU partners, project collaborators, and an international advisory board are involved to meet the international dimension of the problem. Clearly, with this approach ATHON will provide missing critical health hazard information and clarify biological mechanisms underlying the various types of toxicity induced by NDL-PCBs.

Call for proposal

FP6-2004-FOOD-3-B
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Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Väg. 5
Stockholm
Sweden

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Participants (14)

VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV
Belgium
Address
Boeretang 200
Mol

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VETERINARY RESEARCH INSTITUTE
Czechia
Address
Hudcova 70
Brno

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FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE
Spain
Address
Avenida Autopista Del Saler, 16
Valencia

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TERVEYDEN JA HYVINVOINNIN LAITOS (NATIONAL INSTITUTE FOR HEALTH AND WELFARE)
Finland
Address
Mannerheimintie 166
Helsinki

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INSTITUT FÜR WISSENSCHAFT UND FORSCHUNG
Germany
Address
Buerkle De La Camp Platz 1
Bochum

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TECHNISCHE UNIVERSITÄT KAISERSLAUTERN
Germany
Address
Gottlieb-daimler-strasse
Kaiserslautern

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ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI"
Italy
Address
Via Eritrea 62
Milano

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UTRECHT UNIVERSITY
Netherlands
Address
Heidelberglaan 8
Utrecht

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VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG
Netherlands
Address
De Boelelaan 1105
Amsterdam

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UNIVERSITETET I OSLO
Norway
Address
Problemveien 7
Oslo

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UMEA UNIVERSITET
Sweden
Address
Universitetsomradet
Umea

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UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST
United Kingdom
Address
Trust Headquarters, Marlborough St
Bristol

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HEALTH CANADA
Canada
Address
1 De La Columbine, Environmental Health Centre (Building 8), Tunney's Pasture
Ottawa

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DEUTSCHE GESETZLICHE UNFALLVERSICHERUNG EV - DGUV
Germany
Address
Alte Heerstrasse 111
Sankt Augustin

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