Objetivo Tissue culture of cell lines has the potential to replace animal testing, but for such in-vitro approaches to be successful, new and sensitive methods to detect cellular activities are required. ToxiChip will focus on both the development and promotion of alternative in-vitro testing methods for the monitoring of a vast array of toxins, thus alleviating the current demand for animal sacrifice while also permitting high throughput screening. The primary objective is to develop a eukaryote cell based biochip that will be tailored for dual analysis capability (optical and electrochemical) and will be used as a monitoring tool for examining the effects of toxins on a wide range of cell parameters such as, impedance, changes in morphology, distribution and pH.This technology will help to provide an in-depth knowledge of the various cellular responses that occur as a result of toxicity and will have major beneficial implications in such applications as neurology, cytotoxicity and pharmacology. For example in monitoring the overall toxic effects of not only individual chemicals but also combinations of these chemicals in areas such as environmental analysis of wastewater and in drug development. Another objective of this project is to develop a prokaryote based biochip, solely used for detection of toxins using optical analysis only.A panel of genetically engineered bacterial strains that sensitively report on the presence of toxins that normally affect eukaryotic cells, thus eliminating the need to sacrifice animals for experimentation will be developed. In the envisaged system, these bacteria that are immobilised on the prokaryote cell based biochip, will emit a readily measurable signal (fluorescence, bioluminescence, electrochemical etc.) in the presence of different sets of toxins. The developed technology can be adapted to meet the requirements of other potential commercial exploits, in areas such as the pharmaceutical, environmental, health and security sectors. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural scienceschemical scienceselectrochemistryengineering and technologyenvironmental engineeringwater treatment processeswastewater treatment processesnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineneurology Programa(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Tema(s) IST-2004-2.4.2 - Technologies and devices for micro/nano-scale integration Convocatoria de propuestas Data not available Régimen de financiación STREP - Specific Targeted Research Project Coordinador UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK Aportación de la UE Sin datos Dirección WESTERN ROAD CORK Irlanda Ver en el mapa Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo EUROPEAN COMMISSION - JOINT RESERACH CENTRE Bélgica Aportación de la UE Sin datos Dirección - 1049 BRUSSELS Ver en el mapa Coste total Sin datos INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE Rumanía Aportación de la UE Sin datos Dirección EROU IANCU NICOLAE STREET 32B 72225 BUCHAREST Ver en el mapa Coste total Sin datos ISTITUTO SUPERIORE MARIO BOELLA SULLE TECNOLOGIE DELL'INFORMAZIONE E DELLE TELECOMUNICAZIONI Italia Aportación de la UE Sin datos Dirección Via P.C. Boggio 61 TORINO Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos SCIENION AG Alemania Aportación de la UE Sin datos Dirección VOLMERSTRASSE 7A 12489 BERLIN Ver en el mapa Coste total Sin datos TEL AVIV UNIVERSITY Israel Aportación de la UE Sin datos Dirección Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE HEBREW UNIVERSITY OF JERUSALEM Israel Aportación de la UE Sin datos Dirección MT. SCOPUS 91905 JERUSALEM Ver en el mapa Coste total Sin datos VIGICELL Francia Aportación de la UE Sin datos Dirección 13 RUE PASTEUR 94800 VILLEJUIF Ver en el mapa Coste total Sin datos
