NANOINTERACTProject ID: 33231
Development of a platform and toolkit for understanding interactions between nanoparticles and the living world
Total cost:EUR 4 616 544
EU contribution:EUR 3 300 000
Topic(s):NMP-2004-22.214.171.124-2 - Interaction of engineered nanoparticles with the environment and the living world
Call for proposal:FP6-2004-NMP-TI-4See other projects for this call
Funding scheme:STREP - Specific Targeted Research Project
We combine state-of-the-art techniques, methodologies, skills and instrumentation from several scientific arenas to create discipline-independent platforms to address key questions in nanotoxicology. Thus, we identify the routes via which nanoparticles enter and accumulate in living organisms, and connect this to representative cell-nanoparticle systems. Then using the most advanced methods of chemical, physical, biological and toxicological sciences we connect nanoparticle properties (in physiological conditions) to the mechanisms via which they interact with, and disrupt, cellular processes. We establish means and protocols via which every step of the program will be controlled, eliminating the factors that currently cause irreproducibilities. We emphasize novel unbiased assessments of intra- and inter-cellular processes after exposure to nanoparticles, enabling us to explore known, and unknown, processes.
Key companies, large and small from several end-user groups, that are currently facing the challenge of applying nanotechnology in their products are built into the program in a substantial manner, and other key stake-holders are also incorporated into the overall consortium via the Advisory Board. This will ensure maximum uptake of the knowledge generated by NanoInteract, and enable development of Standards for nanoparticle risk assessment.
LEIXLIP, CO KILDARE