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Development of a platform and toolkit for understanding interactions between nanoparticles and the living world

Objective

We combine state-of-the-art techniques, methodologies, skills and instrumentation from several scientific arenas to create discipline-independent platforms to address key questions in nanotoxicology. Thus, we identify the routes via which nanoparticles enter and accumulate in living organisms, and connect this to representative cell-nanoparticle systems. Then using the most advanced methods of chemical, physical, biological and toxicological sciences we connect nanoparticle properties (in physiological conditions) to the mechanisms via which they interact with, and disrupt, cellular processes. We establish means and protocols via which every step of the program will be controlled, eliminating the factors that currently cause irreproducibilities. We emphasize novel unbiased assessments of intra- and inter-cellular processes after exposure to nanoparticles, enabling us to explore known, and unknown, processes.

Key companies, large and small from several end-user groups, that are currently facing the challenge of applying nanotechnology in their products are built into the program in a substantial manner, and other key stake-holders are also incorporated into the overall consortium via the Advisory Board. This will ensure maximum uptake of the knowledge generated by NanoInteract, and enable development of Standards for nanoparticle risk assessment.

Call for proposal

FP6-2004-NMP-TI-4
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Coordinator

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Address
Belfield Campus 4
Dublin
Ireland

Participants (17)

DSM INNOVATION CENTER B.V.
Netherlands
Address
Het Overloon 1
Heerlen
GLANTREO LIMITED
Ireland
Address
Room 323/332, Biotransfer Unit, University College Cork
Cork
INSTYTUT MEDYCYNY PRACY NOFER
Poland
Address
Teresy Street 8
Lodz
INTEL PERFORMANCE LEARNING SOLUTIONS LIMITED
Ireland
Address
Collinstown Industrial Park
Leixlip, Co Kildare
L'OREAL SA
France
Address
14 Rue Royale
Paris
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
München
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5C,
Lund
MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Netherlands
Address
Endepolsdomein 5
Maastricht
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
Address
Antonie Van Leeuwenhoeklaan 9
Bilthoven
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN
Ireland
Address
College Green
Dublin
UMICORE SA/NV
Belgium
Address
Rue Du Marais 31
Bruxelles
UNIVERSITE PARIS SUD
France
Address
Rue Georges Clémenceau 15
Orsay
UNIVERSITEIT GENT
Belgium
Address
Sint Pietersnieuwstraat 25
Gent
UNIVERSITY OF ULSTER
United Kingdom
Address
Cromore Road
Coleraine
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street 1
Rehovot
WILLIAM MARSH RICE UNIVERSITY
United States
Address
6100 South Main
Houston, Texas