Objective One in ten women in the Western world get breast cancer; half die from it. The aim of the proposed work is to detect protein alterations in breast cancer cells to facilitate histological classification and to decipher the molecular pathology. To achieve these goals, a novel high-resolution FTICR mass spectrometer coupled to a state-of-the-art liquid chromatography system will be used for the investigation of patient tissue samples and cellular models. A multi-disciplinary team of medics, biologists, analytical chemists and informaticians will develop essential protocols and novel software.This promising approach builds on three resources:(1) the proteomics knowledge of Juri Rappsilber (team leader),(2) the medical resources of the two largest Italian cancer hospitals, and(3) the excellent molecular oncology expertise of the FIRC Institute for Molecular Oncology Foundation (IFOM) (host).The team has already succeeded in the last months starting its activities and, in addition, impacting through collaborations on the campus and beyond. Expanding the existing team will create a proteomics centre in southern Europe that will act as a location factor of European dimension in terms of granting researchers access to this scarce resource, educating new scientists skilled in proteomics, and counter balancing the efforts in the USA directed on the plasma proteome. If successful, the approach taken in the proposed project and the newly created tools will be applicable to other forms of cancer and create a new branch of molecular diagnosis Fields of science natural sciencescomputer and information sciencessoftwarenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesbasic medicinepathology Keywords bioinformatics blood serum breast cancer cancer stem cells cellular model high-resolution mass spectrometry liquid chromatography software development statistics tissue Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-3.1 - Marie Curie Excellence Grants (EXT) Call for proposal FP6-2002-MOBILITY-8 See other projects for this call Funding Scheme EXT - Marie Curie actions-Grants for Excellent Teams Coordinator THE UNIVERSITY OF EDINBURGH EU contribution No data Address Old College, South Bridge EDINBURGH United Kingdom See on map Links Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE Italy EU contribution No data Address Via Adamello 16 MILAN See on map Links Website Opens in new window Total cost No data
