Objective
One in ten women in the Western world get breast cancer; half die from it. The aim of the proposed work is to detect protein alterations in breast cancer cells to facilitate histological classification and to decipher the molecular pathology. To achieve these goals, a novel high-resolution FTICR mass spectrometer coupled to a state-of-the-art liquid chromatography system will be used for the investigation of patient tissue samples and cellular models. A multi-disciplinary team of medics, biologists, analytical chemists and informaticians will develop essential protocols and novel software.
This promising approach builds on three resources:
(1) the proteomics knowledge of Juri Rappsilber (team leader),
(2) the medical resources of the two largest Italian cancer hospitals, and
(3) the excellent molecular oncology expertise of the FIRC Institute for Molecular Oncology Foundation (IFOM) (host).
The team has already succeeded in the last months starting its activities and, in addition, impacting through collaborations on the campus and beyond. Expanding the existing team will create a proteomics centre in southern Europe that will act as a location factor of European dimension in terms of granting researchers access to this scarce resource, educating new scientists skilled in proteomics, and counter balancing the efforts in the USA directed on the plasma proteome. If successful, the approach taken in the proposed project and the newly created tools will be applicable to other forms of cancer and create a new branch of molecular diagnosis
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.