Objective
b-Amino-a-hydroxy acids are both very important and very powerful intermediates as drug and drugs candidates. b-amino-a-hydroxy acids are the constituent of several natural products which possess biological activity. We describe a new method for the synthesis of the amino acids. The uniqueness of our strategy allow us to modify the functional groups, such as ester, hydroxyl, and carbonyl.
We start from a simple compound, methoxy furan, to form b-hydroxy ester stereoselectively by using the Reformatsky reaction. The employment of the Mitsunobu reaction to b-hydroxy ester derivative will lead the inversion of alcohol to the opposite stereoselectivity. The azidation under the Mitsunobu condition will form azido derivatives with the inversion of stereochemistry.
The oxydation of furan and the reduction of carbonyl group of oxidized furan will yield amino alcohol selectively. At the final stage, ozonolysis of the double bond will be cleaved to an aldehyde which will be oxidized to the b-amino-a-hydroxy amino acids.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ERZURUM
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.