Objetivo b-Amino-a-hydroxy acids are both very important and very powerful intermediates as drug and drugs candidates. b-amino-a-hydroxy acids are the constituent of several natural products which possess biological activity. We describe a new method for the synthesis of the amino acids. The uniqueness of our strategy allow us to modify the functional groups, such as ester, hydroxyl, and carbonyl.We start from a simple compound, methoxy furan, to form b-hydroxy ester stereoselectively by using the Reformatsky reaction. The employment of the Mitsunobu reaction to b-hydroxy ester derivative will lead the inversion of alcohol to the opposite stereoselectivity. The azidation under the Mitsunobu condition will form azido derivatives with the inversion of stereochemistry.The oxydation of furan and the reduction of carbonyl group of oxidized furan will yield amino alcohol selectively. At the final stage, ozonolysis of the double bond will be cleaved to an aldehyde which will be oxidized to the b-amino-a-hydroxy amino acids. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural scienceschemical sciencesorganic chemistryaldehydesnatural scienceschemical scienceselectrochemistryelectrolysisnatural scienceschemical sciencesorganic chemistryalcoholsnatural scienceschemical sciencesorganic chemistryamines Palabras clave Mitsunobu reaction Reformatsky reaction a amino hydroxy acid ozonolysis selective reduction Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Convocatoria de propuestas FP6-2004-MOBILITY-12 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador ATATURK UNIVERSITY Aportación de la UE Sin datos Dirección Rektorluk ERZURUM Turquía Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos