Descripción del proyecto Bio-ICT convergenceThe ReNaChip project aims to develop a biomimetic, biohybrid model that can demonstrate the recovery of a learning response that is lost with age. Mostrar el objetivo del proyecto Ocultar el objetivo del proyecto The objective of this project is to develop a full biohybrid rehabilitation and substitution methodology; replacing the aged cerebellar brain circuit with a biomimetic chip bidirectionally interfaced to the inputs and outputs of the system. Information processing will interface with the cerebellum to actuate a normal, real-time functional behavioural recovery, providing a proof-of-concept test for the functional rehabilitation of more complex neuronal systems.The model neuronal system we have chosen is the cerebellar microcircuit involved in conditioning of the motor eyeblink response. Localized experimental or clinical damage to this microcircuit disrupts irreversibly the eyeblink conditioning while aging invariably compromises the acquisition and retention of the eyeblink response. Using the aged rat as an experimental model we plan to integrate a biomimetic chip to rehabilitate a discrete sensory-motor learning function lost in the senescent cerebellar microcircuit, through the development of multiple enabling technologies. We will develop novel electrodes to both detect the stimulus and trigger the eyeblink response. The stimulus signals will be extracted from background neuronal activity and undergo conditioning, processing and interpretation in a silicon chip which mimics the function of the deficient cerebellar circuit. The output from this biomimetic chip will then trigger the eyeblink response by way of implanted stimulation electrodes.Complete success would be achieved through real-time demonstration of functional recovery of the lost motor learning response in aged rats. Advances in any or all of the component technologies, their integration and clinical implementation, and improved understanding of the neuronal circuit would represent incomplete but valuable progress in the treatment of deficient neuronal systems. Ámbito científico medical and health sciencesclinical medicinephysiotherapynatural scienceschemical sciencesinorganic chemistrymetalloidsnatural sciencescomputer and information sciencesdata sciencedata processing Programa(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Tema(s) ICT-2007.8.3 - Bio-ICT convergence Convocatoria de propuestas FP7-ICT-2007-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP - Collaborative project (generic) Contacto del coordinador Angela SILMON DR. Coordinador UNIVERSITY OF NEWCASTLE UPON TYNE Aportación de la UE € 473 238,00 Dirección KINGS GATE NE1 7RU Newcastle Upon Tyne Reino Unido Ver en el mapa Región North East (England) Northumberland and Tyne and Wear Tyneside Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Douglas Robertson (Dr) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo GUGER TECHNOLOGIES OEG Austria Aportación de la UE € 459 931,00 Dirección HERBERSTEINSTRASSE 60 8020 GRAZ Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Christoph Guger (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos UNIVERSIDAD POMPEU FABRA España Aportación de la UE € 475 826,00 Dirección PLACA DE LA MERCE, 10-12 08002 Barcelona Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Eva Martin (Mrs) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos WINZSOFT (ISRAEL) LTD Israel Aportación de la UE € 206 210,00 Dirección Beit Hillel 3 67017 TEL AVIV-JAFFO Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Abraham Meidan (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos TEL AVIV UNIVERSITY Israel Aportación de la UE € 635 791,00 Dirección RAMAT AVIV 69978 Tel Aviv Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Lea Pais (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ISTITUTO SUPERIORE DI SANITA Italia Aportación de la UE € 40 000,00 Dirección Viale Regina Elena 299 00161 Roma Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Research Organisations Contacto administrativo Rosa Maria Martoccia (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MAX IV Laboratory, Lund University Suecia Aportación de la UE € 308 921,00 Dirección Paradisgatan 5c 22100 LUND Ver en el mapa Región Södra Sverige Sydsverige Skåne län Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Lars Montelius (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
