Objective New high-throughput methods allow generation of massive amounts of molecular biological data. These, mainly phenomenological, data are often difficult to ascribe to the activation of particular signal transduction pathways and/or transcriptional regulators. A way to facilitate data interpretation is to construct gene regulatory networks that include signal transduction mediators, transcriptional regulators and target genes. This is a complex task, not only because of the huge number of molecules involved, but also because of variations across tissues, developmental stages and physiological conditions. However, these networks hold the key to the understanding of the regulatory processes within a cell and, thus, to most life processes in general. The aim of this project is, therefore, to develop a toolbox that combines and puts different high-throughput experimental methods together under the roof of bio- and chemoinformatics, to allow to exploit the full potential of the included methods as well as the generated data. The toolbox will comprise a combination of the most innovative bioinformatic techniques based on databases and methods of artificial intelligence, modern methods of chromatin structure analysis, micro-array technologies, transcription factor-binding site identification, as well as chemoinformatics methods for computer-aided prediction of biological activity spectra. The predictions which will arise during this project from the analysis of the initially generated data, shall lead to new experiments, for validation of the developed method / approach. This toolbox shall provide a cost effective, knowledge-based approach that allows identification of signal transduction mediators and/or transcriptional regulators responsible for certain changes or responses of the cell, in particular those which lead to diseases, thereby facilitating the discovery of new disease targets and consequently the rational design of target-specific drugs. Fields of science natural sciencescomputer and information sciencesartificial intelligencenatural sciencescomputer and information sciencesdatabases Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-1.2.5-4 - Innovative research in post-genomics, which has high potential for application Call for proposal FP6-2005-LIFESCIHEALTH-7 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator BIOBASE GMBH EU contribution No data Address Halchtersche Strasse 33 WOLFENBÜTTEL Germany See on map Links Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all PROGENIKA BIOPHARMA S.A. Spain EU contribution No data Address Parque Tecnologico Zamudio 801-B DERIO See on map Links Website Opens in new window Total cost No data NATIONAL INSTITUTE FOR HEALTH AND WELFARE Finland EU contribution No data Address Mannerheimintie 166 HELSINKI See on map Links Website Opens in new window Total cost No data UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS Germany EU contribution No data Address Robert-Koch-Str. 40 GOETTINGEN See on map Links Website Opens in new window Total cost No data INSTITUTE OF BIOMEDICAL CHEMISTRY OF RUSSIAN ACADEMY OF MEDICAL SCIENCES Russia EU contribution No data Address Pogodinskaya Street, 10 MOSCOW See on map Links Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution No data Address Nobels väg 5 STOCKHOLM See on map Links Website Opens in new window Total cost No data NATIONAL RESEARCH COUNCIL -CNR Italy EU contribution No data Address Piazzale Aldo Moro 7 00185 ROMA RM See on map Links Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V Germany EU contribution No data Address HANSASTRASSE 27 C MÜNCHEN See on map Links Website Opens in new window Total cost No data INSTITUTE OF SYSTEMS BIOLOGY LTD Russia EU contribution No data Address Krasina Street 54, office 901 NOVOSIBIRSK See on map Links Website Opens in new window Total cost No data