Objective
New high-throughput methods allow generation of massive amounts of molecular biological data. These, mainly phenomenological, data are often difficult to ascribe to the activation of particular signal transduction pathways and/or transcriptional regulators. A way to facilitate data interpretation is to construct gene regulatory networks that include signal transduction mediators, transcriptional regulators and target genes. This is a complex task, not only because of the huge number of molecules involved, but also because of variations across tissues, developmental stages and physiological conditions. However, these networks hold the key to the understanding of the regulatory processes within a cell and, thus, to most life processes in general. The aim of this project is, therefore, to develop a toolbox that combines and puts different high-throughput experimental methods together under the roof of bio- and chemoinformatics, to allow to exploit the full potential of the included methods as well as the generated data. The toolbox will comprise a combination of the most innovative bioinformatic techniques based on databases and methods of artificial intelligence, modern methods of chromatin structure analysis, micro-array technologies, transcription factor-binding site identification, as well as chemoinformatics methods for computer-aided prediction of biological activity spectra. The predictions which will arise during this project from the analysis of the initially generated data, shall lead to new experiments, for validation of the developed method / approach. This toolbox shall provide a cost effective, knowledge-based approach that allows identification of signal transduction mediators and/or transcriptional regulators responsible for certain changes or responses of the cell, in particular those which lead to diseases, thereby facilitating the discovery of new disease targets and consequently the rational design of target-specific drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence
- natural sciences computer and information sciences databases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WOLFENBÜTTEL
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.