Recuring breast cancer early genetic diagnostic on a chip

Projektinformationen

RBCE-GENODIAGNOSENS

ID Finanzhilfevereinbarung: 221198

Projekt abgeschlossen

Startdatum 1 März 2008

Enddatum 28 Februar 2010

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 159 166,60

EU-Beitrag € 159 166,60

Koordiniert durch

UNIVERSITAT ROVIRA I VIRGILI
Spain

Ziel

The overall objective of RBCE-GenoDiagnoSens is to exploit breakthroughs at the confluences of micro-, nano- and bio-technologies to initiate the creation of a low-cost minimally-invasive intelligent diagnosis system using a nanotechnology-based device for the early detection of DNA biomarkers involved in breast cancer, especially found in circulating tumour cells (CTCs). The device will consist of an array of nano-biosensors for the consecutive RNA/DNA analysis of cancer cells. The advantages of the exploited biosensors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effectiveness. Death from cancer is usually due to metastases that are formed by hematogenic or lymphatogenic spread of cancer cells from the primary disease site. Fortunately, only a subset of these persist and have the ability to form vascularised macro metastases. Therefore, the quantification and characterisation of circulating tumour cell mRNAs in order to define the metastatic potential is of clinical relevance and may prove valuable for monitoring disease progression and patients response to treatment, and assessing the risk for metastasis or recurrence. With prognostic implications, the quantities of mRNA markers in blood could indicate the stage of cancer progression and the need for more intensive therapeutic intervention to better the outcome of cancer patients. In the frame of the RBCE-GenoDiagnoSens, the leading research scientist will design, taylor and test the optimum surface chemistry for the functionalisation and operation of the nano-biosensors, following his established expertise in the field, while the host institution will provide the complementary knowledge and training in microfabrication, DNA expertise, mass-manufacturing, regulations and commercialisation consideration as routes for the researcher to establish his own autonomy and his progression to become a successful principal investigator within the European Union

Wissenschaftliches Gebiet

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › biological sciences › genetics › DNA
• medical and health sciences › clinical medicine › oncology › breast cancer
• natural sciences › biological sciences › genetics › RNA

Schlüsselbegriffe

• Biophysics
• Biosensor
• Cancer
• Clinical analysis
• DNA
• Diagnostic
• Electrochemist
• Electrochemistry
• Measurement technology
• Nanobiotechnology
• Surface chemistry
• Surface physics
• microfabrication
• microfluidics
• optics

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-2-1-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITAT ROVIRA I VIRGILI

Kontakt Verwaltung

Ciara Kathleen O'sullivan (Dr.)

• EU-Beitrag: € 159 166,60
• Adresse: CARRER DE ESCORXADOR ; 43003 Tarragona ; Spanien
• Region: Este › Cataluña › Tarragona
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten