Obiettivo Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 1600 children at the age of 3 and 5 years and by observing a birth cohort comprising about 320 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country. This proposal is expected to provide new data on the reasons and mechanisms behind the increasing rates of T1D and other immune-mediated diseases seen in most developed countries after World War II. Campo scientifico natural sciencesbiological sciencesgeneticshumanitieshistory and archaeologyhistorymodern historymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineallergology Parole chiave allergy autoimmunity dieatary factors functional genomics genetic susceptibility gut microflora hygiene microbial infections regulatory T cells type 1 diabetes Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.4.3-1 - Early processes in the pathogenesis of type 1 diabetes and strategies for early prevention Invito a presentare proposte FP7-HEALTH-2007-A Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore HELSINGIN YLIOPISTO Contributo UE € 1 604 372,00 Indirizzo YLIOPISTONKATU 3 00014 Helsingin Yliopisto Finlandia Mostra sulla mappa Regione Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Katariina Vainio-Mattila (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto HUS-YHTYMA Finlandia Contributo UE € 494 108,00 Indirizzo STENBACKINKATU 9 00029 Helsinki Mostra sulla mappa Regione Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Tipo di attività Research Organisations Contatto amministrativo Anne Karikumpu (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato SIHTASUTUS TARTU ULIKOOLI KLIINIKUM Estonia Contributo UE € 297 580,00 Indirizzo PUUSEPA 1A 50406 Tartu Mostra sulla mappa Regione Eesti Eesti Lõuna-Eesti Tipo di attività Research Organisations Contatto amministrativo Vallo Tillmann (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Ministry of Health and Social Development, Karelian Republic of the Russian Federation Russia Contributo UE € 191 748,00 Indirizzo Lenin Street, 6 185035 Petrozavodsk Mostra sulla mappa Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contatto amministrativo Valentina Ulich (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TERVEYDEN JA HYVINVOINNIN LAITOS Finlandia Contributo UE € 565 664,00 Indirizzo MANNERHEIMINTIE 166 00271 Helsinki Mostra sulla mappa Regione Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Tipo di attività Research Organisations Contatto amministrativo Jaakko Penttinen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TAMPEREEN YLIOPISTO Finlandia Contributo UE € 993 180,00 Indirizzo Kalevantie 4 33014 TAMPERE Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Hannele Auffermann (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TURUN YLIOPISTO Finlandia Contributo UE € 974 330,00 Indirizzo YLIOPISTONMAKI 20014 Turku Mostra sulla mappa Regione Manner-Suomi Etelä-Suomi Varsinais-Suomi Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eliisa Särkilahti (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TARTU ULIKOOL Estonia Contributo UE € 140 560,00 Indirizzo ULIKOOLI 18 51005 Tartu Mostra sulla mappa Regione Eesti Eesti Lõuna-Eesti Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Raivo Uibo (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato OU IMMUNOTRON Estonia Contributo UE € 49 781,00 Indirizzo Riia 185 51014 TARTU Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Raivo Uibo (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Petrozavodsk State University Russia Contributo UE € 98 729,00 Indirizzo LENIN STREET 33 33 185640 PETROZAVODSK Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Natalya Dorshakova (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germania Contributo UE € 189 592,00 Indirizzo GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Erika Von Mutius (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ACADEMISCH ZIEKENHUIS GRONINGEN Paesi Bassi Contributo UE € 400 256,00 Indirizzo HANZEPLEIN 1 9713 GZ Groningen Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Elisabeth W.H.M. Eijdems (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
