Objective
The aim of the project is the development of electrochemical reactors for the manufacture of fine chemicals with dehydrogenases as a process with almost zero waste emission. The production of enantio pure compounds with high EE’s can be achieved by using dehydrogenases as biocatalysts, because they express high enantio selectivity in ketone reduction, combined with broad substrate spectra by some of these enzymes. These proteins will be engineered for improved catalytic performance using the tools of molecular evolution, modelling, structure prediction, and crystallography. As these dehydrogenases typically require cosubstrate regeneration by aid of a second enzymatic reaction, we are looking for the alternative solution of an electrochemical approach for the regeneration of reduced cofactors. If all active compounds can be functionally immobilized on the electrode surface the constructed reactor would convert the educt in the input flow to the product in the output flow avoiding any contaminations. All necessary components like the mediator, the cofactor and the dehydrogenase will be bound to nano or meso structured electrodes (for increased active surface area) resulting in biofunctionalised surfaces with tailored properties at the nanoscale. Optimization of the electrode materials and surfaces, of the mediators and the required spacers as well as the surface bound dehydrogenase activities will result in electrochemical reactor moduls which can deliver enantio pure synthons for desired compounds in pharmaceutical or agrochemical applications. The obtained data will increase our knowledge on nanostructured catalysts and inorganic-organic hybrid systems. Cheap cofactor regeneration, easy product purification, high selectivity and avoidance of organic solvents will be the advantages of such processes to satisfy the demands of green chemistry in respect of environmentally friendly, flexible and energy efficient productions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry ketones
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences molecular biology molecular evolution
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-NMP-2007-SMALL-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
66123 Saarbrucken
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.