Objective
Membrane proteins are macromolecules of huge academic and biotechnological importance. They account for ~30% of genes in prokaryotic and eukaryotic genomes, and perform a spectrum of essential cellular functions. Despite their importance, these proteins are poorly understood with respect to membrane insertion, folding and complex formation. Even less is known of the interactions between membrane protein complexes, or with other compartments in the cell. This application aims to establish a multidisciplinary initial training network for early-stage researchers in which leading European groups in membrane protein chemistry, bacterial systems biology and biotechnological applications join forces to achieve top-level training in an ambitious academic and industrial setting. Training and research will be fully integrated in a systems approach for the hierarchical analysis of membrane proteins. Key objectives are to understand how individual membrane proteins insert and adopt a unique structure (Research Topic 1), how they assemble into multimeric complexes (Research Topic 2), and how they communicate ('network') with each other and the rest of the cell (Research Topic 3). Novel quantitative approaches combined with mathematical modelling will be used to accurately predict membrane protein behaviour at a systems level (Research Topic 4). Throughout the program, special emphasis will be focused on biotechnologically relevant protein secretion systems. Major scientific deliverables will be knowledge models of complex assembly and inter-complex interaction hubs. The proposed training program will be individually-tailored to provide a coherent grounding in multidisciplinary approaches, both theoretical and experimental. It will deliver network-wide systems biology training, and a comprehensive suite of local complementary skills training. In this way, we will provide our trainees with formidable starting points for careers in European science and industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences knowledge engineering
- natural sciences mathematics applied mathematics mathematical model
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-1-1-ITN
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 8UW COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.