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A systems approach to defining membrane protein networks and applications

Objective

Membrane proteins are macromolecules of huge academic and biotechnological importance. They account for ~30% of genes in prokaryotic and eukaryotic genomes, and perform a spectrum of essential cellular functions. Despite their importance, these proteins are poorly understood with respect to membrane insertion, folding and complex formation. Even less is known of the interactions between membrane protein complexes, or with other compartments in the cell. This application aims to establish a multidisciplinary initial training network for early-stage researchers in which leading European groups in membrane protein chemistry, bacterial systems biology and biotechnological applications join forces to achieve top-level training in an ambitious academic and industrial setting. Training and research will be fully integrated in a systems approach for the hierarchical analysis of membrane proteins. Key objectives are to understand how individual membrane proteins insert and adopt a unique structure (Research Topic 1), how they assemble into multimeric complexes (Research Topic 2), and how they communicate ('network') with each other and the rest of the cell (Research Topic 3). Novel quantitative approaches combined with mathematical modelling will be used to accurately predict membrane protein behaviour at a systems level (Research Topic 4). Throughout the program, special emphasis will be focused on biotechnologically relevant protein secretion systems. Major scientific deliverables will be knowledge models of complex assembly and inter-complex interaction hubs. The proposed training program will be individually-tailored to provide a coherent grounding in multidisciplinary approaches, both theoretical and experimental. It will deliver network-wide systems biology training, and a comprehensive suite of local complementary skills training. In this way, we will provide our trainees with formidable starting points for careers in European science and industry.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-PEOPLE-2007-1-1-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

THE UNIVERSITY OF WARWICK
Address
Kirby Corner Road - University House
CV4 8UW Coventry
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 509 012
Administrative Contact
Kate Hughes (Ms.)

Participants (4)

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 401 017
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anthoni Jan Kee (Dr.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 410 361
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Angelo Trussardi (Mr.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 423 504
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arne Elofsson (Prof.)
NOVOZYMES A/S
Denmark
EU contribution
€ 256 106
Address
Krogshoejvej 36
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Rasmus (Dr.)