Objective
BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g. desiccation or nutrient starvation), stresses as a result of pollution itself (e.g. toxicity), and those during strain preparation and formulation. BACSIN proposes four iterative poles of research and technology to overcome this hindrance for subsequent improved microbial usage. The 1st pole will investigate genome-wide catabolic and stress expression in a set of different pollutant degrading bacteria (the ‘BACSINs’). Key cellular factors and regulatory networks determining the interplay between stress-survival and pollutant catabolism will be unveiled, and faithful predictive models for cell behaviour produced. The 2nd pole will study stress resistance, survival and activity of BACSINs in real polluted environments, via microcosms and in situ ‘traps’, plant roots and leaves, while accentuating possible effects on native communities. The 3d pole will focus on the original microbial communities at contaminated sites, to discover and exploit more optimal stress and survival resistance among resident pollutant-degrading bacteria. We will develop molecular diagnostics tools to screen contaminated sites for catabolic and stress parameters, and decide whether BACSIN complementation should be considered. Promising isolates of resident bacteria will be studied as new BACSINs, to show the usefulness of the ‘diagnosis-isolation-reintroduction’ approach for enhancing pollutant biodegradation rates. Finally, we will focus on BACSIN formulations, to understand the stresses on bacteria during growth, preservation and resuscitation, and to produce optimally active cells for environmental application.
Fields of science
Keywords
Call for proposal
FP7-KBBE-2007-1
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
1015 LAUSANNE
Switzerland
See on map
Participants (15)
18100 ARMILLA GRANADA
See on map
28006 Madrid
See on map
171 00 PRAGUE 7
See on map
405 30 Goeteborg
See on map
38124 Braunschweig
See on map
3000 Leuven
See on map
1011 JV AMSTERDAM
See on map
750 07 Uppsala
See on map
38106 Braunschweig
See on map
04318 Leipzig
See on map
1081 HV AMSTERDAM
See on map
6708 PB Wageningen
See on map
1049 Bruxelles / Brussel
See on map
1211 GENEVA 8
See on map
52440 NOVA VAS (POREC)
See on map