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Bacterial Abiotic Cellular Stress and Survival Improvement Network

Objective

BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g., desiccation or nutrient starvation), stresses as a result of pollution itself (e.g., toxicity), and those during strain preparation and formulation. BACSIN proposes four iterative poles of research and technology to overcome this hindrance for subsequent improved microbial usage. The 1st pole will investigate genome-wide catabolic and stress expression in a set of different pollutant degrading bacteria (the ‘BACSINs’). Key cellular factors and regulatory networks determining the interplay between stress-survival and pollutant catabolism will be unveiled, and faithful predictive models for cell behaviour produced. The 2nd pole will study stress resistance, survival and activity of BACSINs in real polluted environments, via microcosms and in situ ‘traps’, plant roots and leaves, while accentuating possible effects on native communities. The 3d pole will focus on the original microbial communities at contaminated sites, to discover and exploit more optimal stress and survival resistance among resident pollutant-degrading bacteria. We will develop molecular diagnostics tools to screen contaminated sites for catabolic and stress parameters, and decide whether BACSIN complementation should be considered. Promising isolates of resident bacteria will be studied as new BACSINs, to show the usefulness of the ‘diagnosis-isolation-reintroduction’ approach for enhancing pollutant biodegradation rates. Finally, we will focus on BACSIN formulations, to understand the stresses on bacteria during growth, preservation and resuscitation, and to produce optimally active cells for environmental application.

Field of science

  • /natural sciences/earth and related environmental sciences/environmental sciences/pollution

Call for proposal

FP7-KBBE-2007-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE DE LAUSANNE
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 606 839
Administrative Contact
Jan Roelof Van Der Meer (Prof.)

Participants (15)

BIOILIBERIS RESEARCH AND DEVELOPMENT SL
Spain
EU contribution
€ 290 872
Address
Av De La Innovacion 1 Parque Tecnologico De Ciencias Salud
18100 Armilla Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Estrella Ramos (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 403 624
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
María Del Mar García (Ms.)
AECOM CZ SRO
Czechia
EU contribution
€ 191 166
Address
Trojska 92
171 00 Prague 7
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vendulka Spiskova (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 373 097
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 367 198
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Strätz (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 461 068
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 333 942
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other
Administrative Contact
Erwin A Van De Ridder
SVERIGES LANTBRUKSUNIVERSITET
Sweden
EU contribution
€ 441 434
Address
Almas Alle 8
750 07 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingrid Ragnarsdotter (Ms.)
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Germany
EU contribution
€ 370 491
Address
Universitaetsplatz 2
38106 Braunschweig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kenneth Timmis (Prof.)
HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Germany
EU contribution
€ 353 257
Address
Permoserstrasse 15
04318 Leipzig
Activity type
Other
Administrative Contact
Annette Schmidt (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
EU contribution
€ 367 504
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jaap Roos (Mr.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 416 531
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Bosscha (Mr.)
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 203 997
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
Administrative Contact
Arminda Machado (Dr.)
BELAIR BIOTECH Ltd
Switzerland
EU contribution
€ 213 556
Address
Rue Des Bains
1211 Geneva 8
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roland Gerber (Mr.)
ECOENGINEERING
Croatia
EU contribution
€ 135 514
Address
Kestenova
52440 Nova Vas (Porec)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vice šoljan (Dr.)