Objective
Plants sustainably produce low levels of secondary metabolites of high industrial value. However, they are often too complex to be economically manufactured by chemical synthesis. Advanced metabolic engineering and exploitation of plants as Green Factories has been prevented due to poorly understood metabolic pathways in plants and the regulation thereof. SmartCell brings together 14 leading European academic laboratories and four industrial partners in order to create a novel concept for rationally engineering plants towards improved economical production of high-value compounds for non-food industrial use. Although SmartCell focuses on terpenoids, the largest class of secondary metabolites, which exhibit extremely diverse biological and pharmaceutical activities, all knowledge, tools and resources developed in the project, are generic and broadly applicable to engineer any plant biosynthetic pathway. A systems biology approach using metabolomics and transcriptomics is taken to move beyond the state of the art. New multigene transfer technologies are developed. By screening and functionally categorizing genes at structural, regulatory and transport levels a comprehensive knowledge base of how secondary metabolite biosynthetic pathways operate in plants is developed. The case study component i.e. manufacturing a valuable terpenoid in an optimized large-scale system gives SmartCell a unique opportunity to directly make transition from fundamental science to application. For long-term exploitation an integrated database, compound library, cell culture collection and a genebank available for academic and industrial communities will be established. SmartCell provides new opportunities for SMEs and established European biotech companies, and the technology can also be transferred to other e.g. fine chemical and pharmaceutical industries. SmartCell will prove that plant-based resources can furnish the European society and industry far more than they presently do.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology industrial biotechnology metabolic engineering
- natural sciences computer and information sciences databases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-KBBE-2007-2A
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
02044 VTT ESPOO
Finland
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Participants (18)
9052 ZWIJNAARDE - GENT
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2311 EZ Leiden
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25003 Lleida
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80686 MUNCHEN
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8006 ZURICH
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1348 LOUVAIN LA NEUVE
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75794 PARIS
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8401 WINTERTHUR
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NR4 7UH NORWICH
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1165 KOBENHAVN
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80539 MUNCHEN
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OX1 2JD Oxford
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6708 PB Wageningen
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54500 Vandoeuvre Les Nancy
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Participation ended
02150 Espoo
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2000 Neuchatel
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Participation ended
46268-1054 Indianapolis
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92100 Boulogne Billancourt
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