Objective Plants sustainably produce low levels of secondary metabolites of high industrial value. However, they are often too complex to be economically manufactured by chemical synthesis. Advanced metabolic engineering and exploitation of plants as Green Factories has been prevented due to poorly understood metabolic pathways in plants and the regulation thereof. SmartCell brings together 14 leading European academic laboratories and four industrial partners in order to create a novel concept for rationally engineering plants towards improved economical production of high-value compounds for non-food industrial use. Although SmartCell focuses on terpenoids, the largest class of secondary metabolites, which exhibit extremely diverse biological and pharmaceutical activities, all knowledge, tools and resources developed in the project, are generic and broadly applicable to engineer any plant biosynthetic pathway. A systems biology approach using metabolomics and transcriptomics is taken to move beyond the state of the art. New multigene transfer technologies are developed. By screening and functionally categorizing genes at structural, regulatory and transport levels a comprehensive knowledge base of how secondary metabolite biosynthetic pathways operate in plants is developed. The case study component i.e. manufacturing a valuable terpenoid in an optimized large-scale system gives SmartCell a unique opportunity to directly make transition from fundamental science to application. For long-term exploitation an integrated database, compound library, cell culture collection and a genebank available for academic and industrial communities will be established. SmartCell provides new opportunities for SMEs and established European biotech companies, and the technology can also be transferred to other e.g. fine chemical and pharmaceutical industries. SmartCell will prove that plant-based resources can furnish the European society and industry far more than they presently do. Fields of science engineering and technologyindustrial biotechnologymetabolic engineeringnatural sciencescomputer and information sciencesdatabasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Keywords genetic engineering large-scale production manufacturing metabolomics plant plant cells secondary metabolites terpenoids transcriptomics Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE-2007-3-1-09 - GREEN FACTORY – The expression and accumulation of valuable industrial compounds in plants Call for proposal FP7-KBBE-2007-2A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator TEKNOLOGIAN TUTKIMUSKESKUS VTT Address Tekniikantie 4 a 02044 VTT Espoo Finland See on map Activity type Research Organisations Administrative Contact Kirsi-Marja Oksman-Caldentey (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 508 209,00 Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all VIB VZW Belgium EU contribution € 675 377,00 Address Rijvisschestraat 120 9052 Zwijnaarde - gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT LEIDEN Netherlands EU contribution € 505 540,00 Address Rapenburg 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Ton Brouwer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD DE LLEIDA Spain EU contribution € 364 725,00 Address Placa victor siurana 1 1 25003 Lleida See on map Region Este Cataluña Lleida Activity type Higher or Secondary Education Establishments Administrative Contact Josep M. Sentis Suñé (Mr.) Links Contact the organisation Opens in new window Website Opens in new window FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 601 770,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Maximilian Steiert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window University of Zurich Switzerland EU contribution € 184 125,00 Address Ramistrasse 71 8006 Zurich See on map Activity type Higher or Secondary Education Establishments Administrative Contact Enrico Martinoia (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium EU contribution € 222 565,00 Address Place de l universite 1 1348 Louvain la neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Administrative Contact Marc Boutry (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 448 004,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Denis Fix (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN Switzerland EU contribution € 142 821,00 Address Gertrudstrasse 15 8401 Winterthur See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Regine Eibl (Prof.) Links Contact the organisation Opens in new window Website Opens in new window JOHN INNES CENTRE United Kingdom EU contribution € 275 619,00 Address Norwich research park colney NR4 7UH Norwich See on map Region East of England East Anglia Breckland and South Norfolk Activity type Research Organisations Administrative Contact Mary Anderson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KOBENHAVNS UNIVERSITET Denmark EU contribution € 185 852,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 140 802,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Lothar Grube (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 146 906,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Rufus Trotman (Mr.) Links Contact the organisation Opens in new window Website Opens in new window WAGENINGEN UNIVERSITY Netherlands EU contribution € 308 445,00 Address Droevendaalsesteeg 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Higher or Secondary Education Establishments Administrative Contact Harro Bouwmeester (Prof.) Links Contact the organisation Opens in new window Website Opens in new window PLANT ADVANCED TECHNOLOGIES PAT SA France EU contribution € 120 125,00 Address Avenue de la foret de la haye 19 54500 Vandoeuvre les nancy See on map Region Grand Est Lorraine Meurthe-et-Moselle Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jean-Paul Fevre (Mr.) Links Contact the organisation Opens in new window Website Opens in new window SoluCel Oy Participation ended Finland EU contribution € 70 981,00 Address Tietotie 2 02150 Espoo See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Pen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Philip Morris Products S.A. Switzerland EU contribution € 0,00 Address Quai jeanrenaud 56 2000 Neuchatel See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Neuchâtel Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markus Klein (Dr.) Links Contact the organisation Opens in new window Dow AgroSciences LLC Participation ended United States EU contribution € 0,00 Address Zionsville road 9330 46268-1054 Indianapolis See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ronald Maciak (Mr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT DE RECHERCHE PIERRE FABRE France EU contribution € 0,00 Address Place abel gance 45 92100 Boulogne billancourt See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Yves Barbin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
