Objective
Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences molecular biology structural biology
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.