Objective
Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic.
Field of science
- /medical and health sciences/health sciences/public and environmental health
- /natural sciences/biological sciences/molecular biology/structural biology
- /medical and health sciences/health sciences/infectious disease/malaria
Call for proposal
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)
Coordinator
75654 Paris
France
Participants (16)
00161 Roma
SN2 1FL Swindon
20359 Hamburg
WC1E 7HT London
NW1 2BE London
SW17 0RE London
2288 GJ Rijswijk Zh
Participation ended
69120 Heidelberg
75724 Paris Cedex 15
97070 Wuerzburg
G12 8QQ Glasgow
6525 XZ Nijmegen
34149 Trieste
110 067 New Delhi
110067 New Delhi
560012 Bangalore
