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Signalling in life cycle stages of malaria parasites

Objective

Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/health sciences/infectious disease/malaria
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/genetics and heredity/nucleotide
  • /natural sciences/biological sciences/molecular biology/structural biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 472 000
Administrative Contact
Rofigua Hakem (Ms.)

Participants (16)

ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 166 000
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 332 000
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Michele Marron (Ms.)
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany
EU contribution
€ 166 000
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Activity type
Research Organisations
Administrative Contact
Volker Theo Heussler (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 166 000
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Penny Ireland (Ms.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 166 000
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
Elisabeth Muller (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 166 000
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susan Mcpheat (Ms.)
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Netherlands
EU contribution
€ 166 000
Address
Lange Kleiweg 161
2288 GJ Rijswijk Zh
Activity type
Research Organisations
Administrative Contact
Willem Slingerland (Mr.)
UNIVERSITATSKLINIKUM HEIDELBERG

Participation ended

Germany
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
INSTITUT PASTEUR
France
EU contribution
€ 86 000
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 166 000
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Gloggengiesser
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 332 000
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 166 000
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Van Woensel (Mr.)
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Italy
EU contribution
€ 180 000
Address
Padriciano 99
34149 Trieste
Activity type
Research Organisations
Administrative Contact
Chetan Chitnis (Dr.)
JAWAHARLAL NEHRU UNIVERSITY
India
EU contribution
€ 90 000
Address
New Mehrauli Road
110 067 New Delhi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Suman Dhar (Dr.)
NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY
India
EU contribution
€ 90 000
Address
Aruna Asaf Ali Marg
110067 New Delhi
Activity type
Research Organisations
Administrative Contact
Avadhesha Surolia (Prof.)
INDIAN INSTITUTE OF SCIENCE
India
EU contribution
€ 90 000
Address
Cross Malleshwaram 18
560012 Bangalore
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Utpal Tatu (Prof.)