Objective Ubiquitination and deubiquitination of proteins has emerged as an important biological regulatory process. For any investigational and therapeutical purposes, well-defined ubiquitin(-like) conjugates are of prime importance and to date, these have mainly been constructed by enzyme based strategies. However, besides the general potential problems of enzymatic transformations (e.g. yield, isolation, expression), the promiscuous nature of ubiquitination severely limits their general applicability. Despite this and the growing evidence that structural organization of ubiquitin chains is more complicated and important than anticipated, the development of synthetic strategies towards well-defined Ub(ls) has received little attention. This proposal will present synthetic strategies which I believe hold great potential as general approaches towards well-defined ubiquitin conjugates. Chemical approaches and resulting reagents are not only desired for their analytical value but will also assist future developments of targeted therapeutics. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords ubiquitin Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-2-2.ERG - Marie Curie Action: "European Reintegration Grants" Call for proposal FP7-PEOPLE-ERG-2008 See other projects for this call Funding Scheme MC-ERG - European Re-integration Grants (ERG) Coordinator STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS EU contribution € 45 000,00 Address PLESMANLAAN 121 1066 CX Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
